Fractyl Health, Inc. (GUTS) vs Pliant Therapeutics, Inc. (PLRX)

A side-by-side comparison of Fractyl Health, Inc. and Pliant Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

Compare
Fractyl Health, Inc. logo
GUTS
Fractyl Health, Inc.
$60M
$4.54HealthcareDelayed quote: Oct 6, 2026, 3:19 PM EDT
Pliant Therapeutics, Inc. logo
PLRX
Pliant Therapeutics, Inc.
$63M
$1.02HealthcareDelayed quote: Oct 6, 2026, 3:17 PM EDT

Total return — GUTS vs PLRX

growth of $100 · dividends reinvested · last 3y
GUTS -97.0% (-69.1%/yr)PLRX -94.4% (-61.8%/yr)PLRX compounded faster over this window
020406080100Start $10020252026$3$6
GUTS PLRX

GUTS vs PLRX: by the numbers

  • •PLRX is the larger company ($63M vs $60M market cap).

Metrics side by side

Valuation

MetricGUTSPLRX
P/B ratioN/A0.43

Profitability

MetricGUTSPLRX
Gross margin0.00%0.00%
Operating margin0.00%0.00%
Net margin0.00%0.00%
ROEN/A-62.81%
ROIC-129.67%-56.22%

Growth (annualized)

MetricGUTSPLRX
Total return CAGR (5Y)N/A-43.17%

Go deeper

Full GUTS analysisFull PLRX analysisInteractive comparison tool

Dig into the metrics

Fractyl Health ROEPliant Therapeutics ROEFractyl Health operating marginPliant Therapeutics operating marginFractyl Health revenue growthPliant Therapeutics revenue growthFractyl Health free cash flowPliant Therapeutics free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.