Is GSK or ISRG cheaper?

On trailing earnings, GSK is cheaper: GSK trades at a 11.68 P/E and ISRG at 45.77.

Which has grown faster, GSK or ISRG?

Over the past five years, ISRG grew revenue faster — GSK at a 0.63% CAGR versus ISRG at 16.41%.

Does GSK or ISRG pay a bigger dividend?

GSK pays a dividend (3.41% yield) while ISRG does not currently pay one.

Is GSK or ISRG more profitable?

ISRG runs the higher net margin — GSK at 17.76% versus ISRG at 28.45%.

Which has been the better investment, GSK or ISRG?

Over the past 10-year, ISRG delivered the higher annualized total return — GSK at 6.77% versus ISRG at 16.87%. Past performance doesn't predict future results.

GSK plc (GSK) vs Intuitive Surgical, Inc. (ISRG)

GSK leads on 11 of 16 compared metrics.

A side-by-side comparison of GSK plc and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 17, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

GSK

GSK plc

$103.66B

$51.76HealthcareDelayed quote: Jul 17, 2026, 4:00 PM EDT

ISRG

Intuitive Surgical, Inc.

$122.33B

$345.42HealthcareDelayed quote: Jul 17, 2026, 4:00 PM EDT

Total return — GSK vs ISRG

growth of $100 · dividends reinvested · last 26y

GSK +222.3%ISRG +20173.4%ISRG compounded faster

Log scale — wide-divergence pair

GSK ISRG

GSK vs ISRG: by the numbers

•ISRG is the larger company ($122.33B vs $103.66B market cap).
•GSK trades at the lower earnings multiple (11.68 vs 45.77 P/E).
•ISRG converts more revenue to profit (28.45% vs 17.76% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 0.63% CAGR).
•GSK pays a dividend (3.41% yield) while ISRG does not currently pay one.

Which is better, GSK or ISRG?

Metric tally: GSK 11 · ISRG 5

It depends on what you're optimizing for:

ValueGSK(lower P/E)

GrowthISRG(faster 5Y revenue CAGR)

QualityGSK(higher ROIC)

Metrics side by side

Valuation

Metric	GSK	ISRG
P/E ratio	11.68●	45.77
Forward P/E	14.73●	37.76
P/S ratio	2.44●	13.07
P/B ratio	3.45●	7.88
PEG ratio	0.02●	3.17
EV / EBITDA	8.65●	32.04
FCF yield	7.82%●	1.96%

Profitability

Metric	GSK	ISRG
Gross margin	72.67%●	66.68%
Operating margin	25.65%	31.28%●
Net margin	17.76%	28.45%●
ROE	25.19%●	17.15%
ROIC	16.61%●	13.71%

Dividends

Metric	GSK	ISRG
Dividend yield	3.41%	—
Payout ratio	23.74%	—

Growth (annualized)

Metric	GSK	ISRG
Revenue CAGR (5Y)	0.63%	16.41%●
EPS CAGR (5Y)	14.05%	21.51%●
FCF CAGR (5Y)	-0.35%	16.61%●
Total return CAGR (5Y)	10.26%●	2.26%

Frequently asked

Which is better, GSK or ISRG?: It depends on your goal. value: GSK (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: GSK (higher ROIC). Across all compared metrics, GSK leads 11 to 5.
Is GSK or ISRG cheaper?: On trailing earnings, GSK is cheaper: GSK trades at a 11.68 P/E and ISRG at 45.77.
Which has grown faster, GSK or ISRG?: Over the past five years, ISRG grew revenue faster — GSK at a 0.63% CAGR versus ISRG at 16.41%.
Does GSK or ISRG pay a bigger dividend?: GSK pays a dividend (3.41% yield) while ISRG does not currently pay one.
Is GSK or ISRG more profitable?: ISRG runs the higher net margin — GSK at 17.76% versus ISRG at 28.45%.
Which has been the better investment, GSK or ISRG?: Over the past 10-year, ISRG delivered the higher annualized total return — GSK at 6.77% versus ISRG at 16.87%. Past performance doesn't predict future results.

Go deeper

Full GSK analysis Full ISRG analysis Interactive comparison tool

Dig into the metrics

GSK P/E ratio Intuitive Surgical P/E ratio GSK dividend yield Intuitive Surgical dividend yield GSK ROE Intuitive Surgical ROE GSK operating margin Intuitive Surgical operating margin GSK revenue growth Intuitive Surgical revenue growth GSK free cash flow Intuitive Surgical free cash flow

GSK & Intuitive Surgical appear in these rankings

Highest Dividend Yield Stocks Fastest Revenue Growth Stocks Highest ROE Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 17, 2026.