Which has the lower trailing P/E, GSK or ISRG?

GSK has the lower trailing P/E: GSK trades at 16.08 and ISRG at 42.07. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, GSK or ISRG?

Over the past five years, ISRG grew revenue faster — GSK at a 1.38% CAGR versus ISRG at 16.41%.

Does GSK or ISRG pay a bigger dividend?

GSK pays a dividend (3.57% yield), while ISRG has no payments in the available dividend history.

Is GSK or ISRG more profitable?

ISRG runs the higher net margin — GSK at 14.52% versus ISRG at 28.45%.

How have GSK and ISRG total returns compared?

Over the past 10 years, GSK delivered 6.27% and ISRG delivered 17.07% annualized total return. Past performance doesn't predict future results.

GSK plc (GSK) vs Intuitive Surgical, Inc. (ISRG)

A side-by-side comparison of GSK plc and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 4, 2026. Differences are shown without an overall score or investment verdict.

GSK

GSK plc

$99.95B

$49.89HealthcareDelayed quote: Sep 4, 2026, 4:00 PM EDT

ISRG

Intuitive Surgical, Inc.

$129.55B

$366.70HealthcareDelayed quote: Sep 4, 2026, 4:00 PM EDT

Total return — GSK vs ISRG

growth of $100 · dividends reinvested · last 10y

GSK +87.5% (+6.5%/yr)ISRG +382.4% (+17.0%/yr)ISRG compounded faster over this window

GSK ISRG

GSK vs ISRG: by the numbers

•ISRG is the larger company ($129.55B vs $99.95B market cap).
•GSK trades at the lower trailing earnings multiple (16.08 vs 42.07 P/E), one valuation lens rather than an overall verdict.
•ISRG converts more revenue to profit (28.45% vs 14.52% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 1.38% CAGR).
•GSK pays a dividend (3.57% yield), while ISRG has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	GSK	ISRG
P/E ratio	16.08	42.07
Forward P/E	14.19	34.25
P/S ratio	2.33	12.02
P/B ratio	4.44	7.30
EV / EBITDA	8.29	30.68
FCF yield	9.03%	2.43%

Profitability

Metric	GSK	ISRG
Gross margin	72.71%	66.68%
Operating margin	20.72%	31.28%
Net margin	14.52%	28.45%
ROE	27.67%	17.28%
ROIC	13.95%	15.11%

Dividends

Metric	GSK	ISRG
Dividend yield	3.57%	N/A
Payout ratio	47.89%	N/A

Growth (annualized)

Metric	GSK	ISRG
Revenue CAGR (5Y)	1.38%	16.41%
EPS CAGR (5Y)	-0.71%	21.51%
FCF CAGR (5Y)	-2.45%	14.17%
Total return CAGR (5Y)	8.43%	0.69%

Frequently asked

Which has the lower trailing P/E, GSK or ISRG?: GSK has the lower trailing P/E: GSK trades at 16.08 and ISRG at 42.07. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, GSK or ISRG?: Over the past five years, ISRG grew revenue faster — GSK at a 1.38% CAGR versus ISRG at 16.41%.
Does GSK or ISRG pay a bigger dividend?: GSK pays a dividend (3.57% yield), while ISRG has no payments in the available dividend history.
Is GSK or ISRG more profitable?: ISRG runs the higher net margin — GSK at 14.52% versus ISRG at 28.45%.
How have GSK and ISRG total returns compared?: Over the past 10 years, GSK delivered 6.27% and ISRG delivered 17.07% annualized total return. Past performance doesn't predict future results.

Go deeper

Full GSK analysis Full ISRG analysis Interactive comparison tool

Dig into the metrics

GSK P/E ratio Intuitive Surgical P/E ratio GSK dividend yield GSK ROE Intuitive Surgical ROE GSK operating margin Intuitive Surgical operating margin GSK revenue growth Intuitive Surgical revenue growth GSK free cash flow Intuitive Surgical free cash flow

GSK & Intuitive Surgical appear in these rankings

Highest Dividend Yield Stocks Fastest Revenue Growth Stocks Highest ROE Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 4, 2026.