Which has the lower trailing P/E, GMED or KRYS?

GMED has the lower trailing P/E: GMED trades at 19.69 and KRYS at 41.46. P/E is one valuation measure and does not by itself establish which business is cheaper.

Is GMED or KRYS more profitable?

KRYS runs the higher net margin — GMED at 17.03% versus KRYS at 54.82%.

How have GMED and KRYS total returns compared?

Over the past 5 years, GMED delivered -0.44% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Globus Medical, Inc. (GMED) vs Krystal Biotech, Inc. (KRYS)

A side-by-side comparison of Globus Medical, Inc. and Krystal Biotech, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

GMED

Globus Medical, Inc.

$10.33B

$76.58HealthcareDelayed quote: Oct 6, 2026, 11:40 AM EDT

KRYS

Krystal Biotech, Inc.

$9.75B

$330.83HealthcareDelayed quote: Oct 6, 2026, 11:40 AM EDT

Total return — GMED vs KRYS

growth of $100 · dividends reinvested · last 9y

GMED +154.3% (+10.9%/yr)KRYS +3047.1% (+46.7%/yr)KRYS compounded faster over this window

Log scale — wide-divergence pair

GMED KRYS

GMED vs KRYS: by the numbers

•GMED is the larger company ($10.33B vs $9.75B market cap).
•GMED trades at the lower trailing earnings multiple (19.69 vs 41.46 P/E), one valuation lens rather than an overall verdict.
•KRYS converts more revenue to profit (54.82% vs 17.03% net margin).

Metrics side by side

Valuation

Metric	GMED	KRYS
P/E ratio	19.69	41.46
Forward P/E	15.31	43.49
PEG ratio	0.63	N/A
P/S ratio	3.28	22.14
P/B ratio	2.17	7.18
EV / EBITDA	10.64	45.67
FCF yield	7.27%	2.64%

Profitability

Metric	GMED	KRYS
Gross margin	68.55%	93.34%
Operating margin	20.75%	44.93%
Net margin	17.03%	54.82%
ROE	11.23%	17.77%
ROIC	10.49%	14.41%

Growth (annualized)

Metric	GMED	KRYS
Revenue CAGR (5Y)	27.65%	N/A
EPS CAGR (5Y)	30.79%	N/A
FCF CAGR (5Y)	29.93%	N/A
Total return CAGR (5Y)	-0.44%	44.28%

Frequently asked

Which has the lower trailing P/E, GMED or KRYS?: GMED has the lower trailing P/E: GMED trades at 19.69 and KRYS at 41.46. P/E is one valuation measure and does not by itself establish which business is cheaper.
Is GMED or KRYS more profitable?: KRYS runs the higher net margin — GMED at 17.03% versus KRYS at 54.82%.
How have GMED and KRYS total returns compared?: Over the past 5 years, GMED delivered -0.44% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Go deeper

Full GMED analysis Full KRYS analysis Interactive comparison tool

Dig into the metrics

Globus Medical P/E ratio Krystal Biotech P/E ratio Globus Medical ROE Krystal Biotech ROE Globus Medical operating margin Krystal Biotech operating margin Globus Medical revenue growth Krystal Biotech revenue growth Globus Medical free cash flow Krystal Biotech free cash flow

Globus Medical & Krystal Biotech appear in these rankings

Fastest Revenue Growth Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.