Is GILD or ISRG cheaper?

On trailing earnings, GILD is cheaper: GILD trades at a 17.11 P/E and ISRG at 49.83.

Which has grown faster, GILD or ISRG?

Over the past five years, ISRG grew revenue faster — GILD at a 3.07% CAGR versus ISRG at 18.39%.

Does GILD or ISRG pay a bigger dividend?

GILD pays a dividend (1.91% yield) while ISRG does not currently pay one.

Is GILD or ISRG more profitable?

GILD runs the higher net margin — GILD at 30.99% versus ISRG at 28.15%.

Which has been the better investment, GILD or ISRG?

Over the past 10-year, ISRG delivered the higher annualized total return — GILD at 7.79% versus ISRG at 19.14%. Past performance doesn't predict future results.

Gilead Sciences, Inc. (GILD) vs Intuitive Surgical, Inc. (ISRG)

GILD leads on 14 of 16 compared metrics.

A side-by-side comparison of Gilead Sciences, Inc. and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 13, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

GILD

Gilead Sciences, Inc.

$155.93B

$125.59Healthcare

ISRG

Intuitive Surgical, Inc.

$145.58B

$411.06Healthcare

Total return — GILD vs ISRG

growth of $100 · last 26y

GILD +6026.3%ISRG +20149.3%ISRG compounded faster

GILD ISRG

GILD vs ISRG: by the numbers

•GILD is the larger company ($155.93B vs $145.58B market cap).
•GILD trades at the lower earnings multiple (17.11 vs 49.83 P/E).
•GILD converts more revenue to profit (30.99% vs 28.15% net margin).
•ISRG grew revenue faster over the past five years (18.39% vs 3.07% CAGR).
•GILD pays a dividend (1.91% yield) while ISRG does not currently pay one.

Which is better, GILD or ISRG?

Metric tally: GILD 14 · ISRG 2

It depends on what you're optimizing for:

ValueGILD(lower P/E)

GrowthISRG(faster 5Y revenue CAGR)

QualityGILD(higher ROIC)

Valuation

Metric	GILD	ISRG
P/E ratio	17.11●	49.83
Forward P/E	13.00●	34.90
P/S ratio	5.30●	13.98
P/B ratio	6.70●	8.46
PEG ratio	0.01●	3.17
EV / EBITDA	12.91●	35.41
FCF yield	6.49%●	1.92%

Profitability

Metric	GILD	ISRG
Gross margin	79.35%●	66.29%
Operating margin	38.26%●	30.45%
Net margin	30.99%●	28.15%
ROE	39.19%●	17.05%
ROIC	21.53%●	13.71%

Dividends

Metric	GILD	ISRG
Dividend yield	1.91%	—
Payout ratio	35.09%	—

Growth (annualized)

Metric	GILD	ISRG
Revenue CAGR (5Y)	3.07%	18.39%●
EPS CAGR (5Y)	133.83%●	21.51%
FCF CAGR (5Y)	3.30%	16.61%●
Total return CAGR (5Y)	17.06%●	7.37%

Frequently asked

Which is better, GILD or ISRG?: It depends on your goal. value: GILD (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: GILD (higher ROIC). Across all compared metrics, GILD leads 14 to 2.
Is GILD or ISRG cheaper?: On trailing earnings, GILD is cheaper: GILD trades at a 17.11 P/E and ISRG at 49.83.
Which has grown faster, GILD or ISRG?: Over the past five years, ISRG grew revenue faster — GILD at a 3.07% CAGR versus ISRG at 18.39%.
Does GILD or ISRG pay a bigger dividend?: GILD pays a dividend (1.91% yield) while ISRG does not currently pay one.
Is GILD or ISRG more profitable?: GILD runs the higher net margin — GILD at 30.99% versus ISRG at 28.15%.
Which has been the better investment, GILD or ISRG?: Over the past 10-year, ISRG delivered the higher annualized total return — GILD at 7.79% versus ISRG at 19.14%. Past performance doesn't predict future results.

Go deeper

Full GILD analysis Full ISRG analysis Interactive comparison tool

Dig into the metrics

Gilead Sciences P/E ratio Intuitive Surgical P/E ratio Gilead Sciences dividend yield Intuitive Surgical dividend yield Gilead Sciences ROE Intuitive Surgical ROE Gilead Sciences operating margin Intuitive Surgical operating margin Gilead Sciences revenue growth Intuitive Surgical revenue growth Gilead Sciences free cash flow Intuitive Surgical free cash flow

Gilead Sciences & Intuitive Surgical appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 13, 2026.