4D Molecular Therapeutics, Inc. (FDMT) vs Ironwood Pharmaceuticals, Inc. (IRWD)
A side-by-side comparison of 4D Molecular Therapeutics, Inc. and Ironwood Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
FDMT
4D Molecular Therapeutics, Inc.
$12.77HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT
IRWD
Ironwood Pharmaceuticals, Inc.
$3.65HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT
Total return — FDMT vs IRWD
growth of $100 · dividends reinvested · last 6yFDMT -68.1% (-17.3%/yr)IRWD -69.0% (-17.7%/yr)FDMT compounded faster over this window
FDMT IRWD
FDMT vs IRWD: by the numbers
- •FDMT is the larger company ($667M vs $600M market cap).
- •IRWD is profitable (33.36% net margin) while FDMT runs a net loss (-194.74%).
- •FDMT grew revenue faster over the past five years (31.93% vs -1.18% CAGR).
Metrics side by side
Valuation
| Metric | FDMT | IRWD |
|---|---|---|
| P/E ratio | N/A | 4.75 |
| Forward P/E | N/A | 2.98 |
| P/S ratio | 7.25 | 1.54 |
| P/B ratio | 1.64 | N/A |
| EV / EBITDA | N/A | 3.86 |
| FCF yield | N/A | 30.92% |
Profitability
| Metric | FDMT | IRWD |
|---|---|---|
| Gross margin | 91.05% | 99.76% |
| Operating margin | -187.24% | 40.10% |
| Net margin | -194.74% | 33.36% |
| ROE | -43.95% | N/A |
| ROIC | -44.30% | 58.60% |
Growth (annualized)
| Metric | FDMT | IRWD |
|---|---|---|
| Revenue CAGR (5Y) | 31.93% | -1.18% |
| EPS CAGR (5Y) | N/A | -25.87% |
| FCF CAGR (5Y) | N/A | -3.98% |
| Total return CAGR (5Y) | -13.08% | -22.82% |
Frequently asked
- Which has grown faster, FDMT or IRWD?
- Over the past five years, FDMT grew revenue faster — FDMT at a 31.93% CAGR versus IRWD at -1.18%.
- Is FDMT or IRWD more profitable?
- IRWD runs the higher net margin — FDMT at -194.74% versus IRWD at 33.36%.
- How have FDMT and IRWD total returns compared?
- Over the past 5 years, FDMT delivered -13.08% and IRWD delivered -22.82% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Ironwood Pharmaceuticals P/E ratio4D Molecular Therapeutics ROEIronwood Pharmaceuticals ROE4D Molecular Therapeutics operating marginIronwood Pharmaceuticals operating margin4D Molecular Therapeutics revenue growthIronwood Pharmaceuticals revenue growth4D Molecular Therapeutics free cash flowIronwood Pharmaceuticals free cash flow
4D Molecular Therapeutics & Ironwood Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.