Which has the lower trailing P/E, FBIO or SPRO?

FBIO has the lower trailing P/E: FBIO trades at 0.77 and SPRO at 10.78. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, FBIO or SPRO?

Over the past five years, SPRO grew revenue faster — FBIO at a 5.39% CAGR versus SPRO at 22.93%.

Is FBIO or SPRO more profitable?

FBIO runs the higher net margin — FBIO at 163.32% versus SPRO at 17.18%.

How have FBIO and SPRO total returns compared?

Over the past 5 years, FBIO delivered -46.06% and SPRO delivered -42.70% annualized total return. Past performance doesn't predict future results.

Fortress Biotech, Inc. (FBIO) vs Spero Therapeutics, Inc. (SPRO)

A side-by-side comparison of Fortress Biotech, Inc. and Spero Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

FBIO

Fortress Biotech, Inc.

$69M

$2.07HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

SPRO

Spero Therapeutics, Inc.

$69M

$1.19HealthcareDelayed quote: Oct 6, 2026, 3:30 PM EDT

Total return — FBIO vs SPRO

growth of $100 · dividends reinvested · last 9y

FBIO -96.3% (-30.7%/yr)SPRO -89.9% (-22.5%/yr)SPRO compounded faster over this window

FBIO SPRO

FBIO vs SPRO: by the numbers

•SPRO is the larger company ($69M vs $69M market cap).
•FBIO trades at the lower trailing earnings multiple (0.77 vs 10.78 P/E), one valuation lens rather than an overall verdict.
•FBIO converts more revenue to profit (163.32% vs 17.18% net margin).
•SPRO grew revenue faster over the past five years (22.93% vs 5.39% CAGR).

Metrics side by side

Valuation

Metric	FBIO	SPRO
P/E ratio	0.77	10.78
P/S ratio	1.00	1.60
P/B ratio	0.42	1.55
EV / EBITDA	N/A	3.31
FCF yield	183.45%	28.51%

Profitability

Metric	FBIO	SPRO
Gross margin	62.53%	100.00%
Operating margin	-111.00%	-0.04%
Net margin	163.32%	17.18%
ROE	68.12%	16.70%
ROIC	-10.85%	13.12%

Growth (annualized)

Metric	FBIO	SPRO
Revenue CAGR (5Y)	5.39%	22.93%
Total return CAGR (5Y)	-46.06%	-42.70%

Frequently asked

Which has the lower trailing P/E, FBIO or SPRO?: FBIO has the lower trailing P/E: FBIO trades at 0.77 and SPRO at 10.78. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, FBIO or SPRO?: Over the past five years, SPRO grew revenue faster — FBIO at a 5.39% CAGR versus SPRO at 22.93%.
Is FBIO or SPRO more profitable?: FBIO runs the higher net margin — FBIO at 163.32% versus SPRO at 17.18%.
How have FBIO and SPRO total returns compared?: Over the past 5 years, FBIO delivered -46.06% and SPRO delivered -42.70% annualized total return. Past performance doesn't predict future results.

Go deeper

Full FBIO analysis Full SPRO analysis Interactive comparison tool

Dig into the metrics

Fortress Biotech P/E ratio Spero Therapeutics P/E ratio Fortress Biotech ROE Spero Therapeutics ROE Fortress Biotech operating margin Spero Therapeutics operating margin Fortress Biotech revenue growth Spero Therapeutics revenue growth Fortress Biotech free cash flow Spero Therapeutics free cash flow

Fortress Biotech & Spero Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.