Which has the lower trailing P/E, EXEL or PEN?

EXEL has the lower trailing P/E: EXEL trades at 17.32 and PEN at 79.08. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, EXEL or PEN?

Over the past five years, PEN grew revenue faster — EXEL at a 16.06% CAGR versus PEN at 17.52%.

Is EXEL or PEN more profitable?

EXEL runs the higher net margin — EXEL at 35.33% versus PEN at 10.67%.

How have EXEL and PEN total returns compared?

Over the past 10 years, EXEL delivered 17.56% and PEN delivered 16.18% annualized total return. Past performance doesn't predict future results.

Exelixis, Inc. (EXEL) vs Penumbra, Inc. (PEN)

A side-by-side comparison of Exelixis, Inc. and Penumbra, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 28, 2026. Differences are shown without an overall score or investment verdict.

EXEL

Exelixis, Inc.

$13.69B

$54.45HealthcareDelayed quote: Aug 28, 2026, 4:00 PM EDT

PEN

Penumbra, Inc.

$12.67B

$321.68HealthcareDelayed quote: Aug 28, 2026, 4:00 PM EDT

Total return — EXEL vs PEN

growth of $100 · dividends reinvested · last 10y

EXEL +404.2% (+17.6%/yr)PEN +359.7% (+16.5%/yr)EXEL compounded faster over this window

EXEL PEN

EXEL vs PEN: by the numbers

•EXEL is the larger company ($13.69B vs $12.67B market cap).
•EXEL trades at the lower trailing earnings multiple (17.32 vs 79.08 P/E), one valuation lens rather than an overall verdict.
•EXEL converts more revenue to profit (35.33% vs 10.67% net margin).
•PEN grew revenue faster over the past five years (17.52% vs 16.06% CAGR).

Metrics side by side

Valuation

Metric	EXEL	PEN
P/E ratio	17.32	79.08
Forward P/E	18.54	68.36
P/S ratio	5.89	8.46
P/B ratio	7.78	8.32
EV / EBITDA	14.24	62.32
FCF yield	8.23%	1.70%

Profitability

Metric	EXEL	PEN
Gross margin	96.48%	67.84%
Operating margin	39.88%	12.45%
Net margin	35.33%	10.67%
ROE	46.68%	10.49%
ROIC	37.87%	8.48%

Growth (annualized)

Metric	EXEL	PEN
Revenue CAGR (5Y)	16.06%	17.52%
EPS CAGR (5Y)	51.51%	21.94%
FCF CAGR (5Y)	40.17%	83.74%
Total return CAGR (5Y)	23.25%	3.44%

Frequently asked

Which has the lower trailing P/E, EXEL or PEN?: EXEL has the lower trailing P/E: EXEL trades at 17.32 and PEN at 79.08. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, EXEL or PEN?: Over the past five years, PEN grew revenue faster — EXEL at a 16.06% CAGR versus PEN at 17.52%.
Is EXEL or PEN more profitable?: EXEL runs the higher net margin — EXEL at 35.33% versus PEN at 10.67%.
How have EXEL and PEN total returns compared?: Over the past 10 years, EXEL delivered 17.56% and PEN delivered 16.18% annualized total return. Past performance doesn't predict future results.

Go deeper

Full EXEL analysis Full PEN analysis Interactive comparison tool

Dig into the metrics

Exelixis P/E ratio Penumbra P/E ratio Exelixis ROE Penumbra ROE Exelixis operating margin Penumbra operating margin Exelixis revenue growth Penumbra revenue growth Exelixis free cash flow Penumbra free cash flow

Exelixis & Penumbra appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 28, 2026.