Which has the lower trailing P/E, EXEL or NBIX?

EXEL has the lower trailing P/E: EXEL trades at 18.29 and NBIX at 21.34. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, EXEL or NBIX?

Over the past five years, NBIX grew revenue faster — EXEL at a 16.06% CAGR versus NBIX at 26.74%.

Is EXEL or NBIX more profitable?

EXEL runs the higher net margin — EXEL at 35.33% versus NBIX at 20.91%.

How have EXEL and NBIX total returns compared?

Over the past 10 years, EXEL delivered 16.20% and NBIX delivered 10.90% annualized total return. Past performance doesn't predict future results.

Exelixis, Inc. (EXEL) vs Neurocrine Biosciences, Inc. (NBIX)

A side-by-side comparison of Exelixis, Inc. and Neurocrine Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

EXEL

Exelixis, Inc.

$14.66B

$58.33HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

NBIX

Neurocrine Biosciences, Inc.

$14.63B

$145.51HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — EXEL vs NBIX

growth of $100 · dividends reinvested · last 10y

EXEL +346.5% (+16.1%/yr)NBIX +186.9% (+11.1%/yr)EXEL compounded faster over this window

EXEL NBIX

EXEL vs NBIX: by the numbers

•EXEL is the larger company ($14.66B vs $14.63B market cap).
•EXEL trades at the lower trailing earnings multiple (18.29 vs 21.34 P/E), one valuation lens rather than an overall verdict.
•EXEL converts more revenue to profit (35.33% vs 20.91% net margin).
•NBIX grew revenue faster over the past five years (26.74% vs 16.06% CAGR).

Metrics side by side

Valuation

Metric	EXEL	NBIX
P/E ratio	18.29	21.34
Forward P/E	16.61	20.60
PEG ratio	0.36	9.12
P/S ratio	6.02	4.34
P/B ratio	7.95	3.96
EV / EBITDA	14.55	17.58
FCF yield	7.90%	5.92%

Profitability

Metric	EXEL	NBIX
Gross margin	96.48%	97.97%
Operating margin	39.88%	23.38%
Net margin	35.33%	20.91%
ROE	46.68%	19.10%
ROIC	37.87%	13.20%

Growth (annualized)

Metric	EXEL	NBIX
Revenue CAGR (5Y)	16.06%	26.74%
EPS CAGR (5Y)	51.51%	1.94%
FCF CAGR (5Y)	39.63%	28.69%
Total return CAGR (5Y)	23.00%	7.56%

Frequently asked

Which has the lower trailing P/E, EXEL or NBIX?: EXEL has the lower trailing P/E: EXEL trades at 18.29 and NBIX at 21.34. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, EXEL or NBIX?: Over the past five years, NBIX grew revenue faster — EXEL at a 16.06% CAGR versus NBIX at 26.74%.
Is EXEL or NBIX more profitable?: EXEL runs the higher net margin — EXEL at 35.33% versus NBIX at 20.91%.
How have EXEL and NBIX total returns compared?: Over the past 10 years, EXEL delivered 16.20% and NBIX delivered 10.90% annualized total return. Past performance doesn't predict future results.

Go deeper

Full EXEL analysis Full NBIX analysis Interactive comparison tool

Dig into the metrics

Exelixis P/E ratio Neurocrine Biosciences P/E ratio Exelixis ROE Neurocrine Biosciences ROE Exelixis operating margin Neurocrine Biosciences operating margin Exelixis revenue growth Neurocrine Biosciences revenue growth Exelixis free cash flow Neurocrine Biosciences free cash flow

Exelixis & Neurocrine Biosciences appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.