Which has the lower trailing P/E, EXEL or ICLR?

EXEL has the lower trailing P/E: EXEL trades at 18.45 and ICLR at 39.51. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, EXEL or ICLR?

Over the past five years, ICLR grew revenue faster — EXEL at a 16.06% CAGR versus ICLR at 20.93%.

Is EXEL or ICLR more profitable?

EXEL runs the higher net margin — EXEL at 35.33% versus ICLR at 3.99%.

How have EXEL and ICLR total returns compared?

Over the past 10 years, EXEL delivered 16.39% and ICLR delivered 7.67% annualized total return. Past performance doesn't predict future results.

Exelixis, Inc. (EXEL) vs ICON Public Limited Company (ICLR)

A side-by-side comparison of Exelixis, Inc. and ICON Public Limited Company across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 5, 2026. Differences are shown without an overall score or investment verdict.

EXEL

Exelixis, Inc.

$14.79B

$58.85HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

ICLR

ICON Public Limited Company

$12.89B

$168.33HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

Total return — EXEL vs ICLR

growth of $100 · dividends reinvested · last 10y

EXEL +343.0% (+16.0%/yr)ICLR +112.9% (+7.8%/yr)EXEL compounded faster over this window

EXEL ICLR

EXEL vs ICLR: by the numbers

•EXEL is the larger company ($14.79B vs $12.89B market cap).
•EXEL trades at the lower trailing earnings multiple (18.45 vs 39.51 P/E), one valuation lens rather than an overall verdict.
•EXEL converts more revenue to profit (35.33% vs 3.99% net margin).
•ICLR grew revenue faster over the past five years (20.93% vs 16.06% CAGR).

Metrics side by side

Valuation

Metric	EXEL	ICLR
P/E ratio	18.45	39.51
Forward P/E	16.75	15.90
PEG ratio	0.36	N/A
P/S ratio	6.07	1.56
P/B ratio	8.02	1.37
EV / EBITDA	14.68	10.94
FCF yield	7.83%	10.44%

Profitability

Metric	EXEL	ICLR
Gross margin	96.48%	21.85%
Operating margin	39.88%	10.15%
Net margin	35.33%	3.99%
ROE	46.68%	3.51%
ROIC	37.87%	4.80%

Growth (annualized)

Metric	EXEL	ICLR
Revenue CAGR (5Y)	16.06%	20.93%
EPS CAGR (5Y)	51.51%	-14.23%
FCF CAGR (5Y)	39.63%	22.10%
Total return CAGR (5Y)	22.06%	-9.18%

Frequently asked

Which has the lower trailing P/E, EXEL or ICLR?: EXEL has the lower trailing P/E: EXEL trades at 18.45 and ICLR at 39.51. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, EXEL or ICLR?: Over the past five years, ICLR grew revenue faster — EXEL at a 16.06% CAGR versus ICLR at 20.93%.
Is EXEL or ICLR more profitable?: EXEL runs the higher net margin — EXEL at 35.33% versus ICLR at 3.99%.
How have EXEL and ICLR total returns compared?: Over the past 10 years, EXEL delivered 16.39% and ICLR delivered 7.67% annualized total return. Past performance doesn't predict future results.

Go deeper

Full EXEL analysis Full ICLR analysis Interactive comparison tool

Dig into the metrics

Exelixis P/E ratio ICON Public P/E ratio Exelixis ROE ICON Public ROE Exelixis operating margin ICON Public operating margin Exelixis revenue growth ICON Public revenue growth Exelixis free cash flow ICON Public free cash flow

Exelixis & ICON Public appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 5, 2026.