Which has the lower trailing P/E, EW or ILMN?

EW has the lower trailing P/E: EW trades at 48.94 and ILMN at 50.94. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, EW or ILMN?

Over the past five years, EW grew revenue faster — EW at a 5.75% CAGR versus ILMN at 5.04%.

Is EW or ILMN more profitable?

ILMN runs the higher net margin — EW at 15.43% versus ILMN at 18.36%.

How have EW and ILMN total returns compared?

Over the past 10 years, EW delivered 7.80% and ILMN delivered 4.17% annualized total return. Past performance doesn't predict future results.

Edwards Lifesciences Corporation (EW) vs Illumina, Inc. (ILMN)

A side-by-side comparison of Edwards Lifesciences Corporation and Illumina, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 2, 2026. Differences are shown without an overall score or investment verdict.

Edwards Lifesciences Corporation

$49.03B

$85.15HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

ILMN

Illumina, Inc.

$41.31B

$273.04HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

Total return — EW vs ILMN

growth of $100 · dividends reinvested · last 10y

EW +113.0% (+7.9%/yr)ILMN +51.1% (+4.2%/yr)EW compounded faster over this window

EW ILMN

EW vs ILMN: by the numbers

•EW is the larger company ($49.03B vs $41.31B market cap).
•EW trades at the lower trailing earnings multiple (48.94 vs 50.94 P/E), one valuation lens rather than an overall verdict.
•ILMN converts more revenue to profit (18.36% vs 15.43% net margin).
•EW grew revenue faster over the past five years (5.75% vs 5.04% CAGR).

Metrics side by side

Valuation

Metric	EW	ILMN
P/E ratio	48.94	50.94
Forward P/E	28.37	51.00
PEG ratio	6.91	11.99
P/S ratio	7.53	9.19
P/B ratio	4.62	14.56
EV / EBITDA	23.47	35.22
FCF yield	2.92%	2.27%

Profitability

Metric	EW	ILMN
Gross margin	77.98%	66.79%
Operating margin	28.09%	20.97%
Net margin	15.43%	18.36%
ROE	9.46%	29.07%
ROIC	10.22%	13.74%

Growth (annualized)

Metric	EW	ILMN
Revenue CAGR (5Y)	5.75%	5.04%
EPS CAGR (5Y)	6.87%	4.22%
FCF CAGR (5Y)	6.41%	1.03%
Total return CAGR (5Y)	-5.37%	-7.09%

Frequently asked

Which has the lower trailing P/E, EW or ILMN?: EW has the lower trailing P/E: EW trades at 48.94 and ILMN at 50.94. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, EW or ILMN?: Over the past five years, EW grew revenue faster — EW at a 5.75% CAGR versus ILMN at 5.04%.
Is EW or ILMN more profitable?: ILMN runs the higher net margin — EW at 15.43% versus ILMN at 18.36%.
How have EW and ILMN total returns compared?: Over the past 10 years, EW delivered 7.80% and ILMN delivered 4.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full EW analysis Full ILMN analysis Interactive comparison tool

Dig into the metrics

Edwards Lifesciences P/E ratio Illumina P/E ratio Edwards Lifesciences ROE Illumina ROE Edwards Lifesciences operating margin Illumina operating margin Edwards Lifesciences revenue growth Illumina revenue growth Edwards Lifesciences free cash flow Illumina free cash flow

Edwards Lifesciences & Illumina appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 2, 2026.