Is ETON or STOK more profitable?

ETON runs the higher net margin — ETON at 12.02% versus STOK at -753.60%.

How have ETON and STOK total returns compared?

Over the past 5 years, ETON delivered 63.04% and STOK delivered -0.24% annualized total return. Past performance doesn't predict future results.

Eton Pharmaceuticals, Inc. (ETON) vs Stoke Therapeutics, Inc. (STOK)

A side-by-side comparison of Eton Pharmaceuticals, Inc. and Stoke Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ETON

Eton Pharmaceuticals, Inc.

$1.51B

$55.12HealthcareDelayed quote: Oct 6, 2026, 2:20 PM EDT

STOK

Stoke Therapeutics, Inc.

$1.56B

$24.19HealthcareDelayed quote: Oct 6, 2026, 2:15 PM EDT

Total return — ETON vs STOK

growth of $100 · dividends reinvested · last 7y

ETON +655.7% (+33.5%/yr)STOK -1.0% (-0.1%/yr)ETON compounded faster over this window

Log scale — wide-divergence pair

ETON STOK

ETON vs STOK: by the numbers

•STOK is the larger company ($1.56B vs $1.51B market cap).
•ETON is profitable (12.02% net margin) while STOK runs a net loss (-753.60%).

Metrics side by side

Valuation

Metric	ETON	STOK
P/E ratio	143.32	N/A
Forward P/E	50.69	N/A
P/S ratio	14.30	56.57
P/B ratio	32.41	4.52
EV / EBITDA	72.51	N/A
FCF yield	0.98%	N/A

Profitability

Metric	ETON	STOK
Gross margin	57.87%	100.00%
Operating margin	0.09%	-11.16%
Net margin	12.02%	-753.60%
ROE	27.24%	-60.17%
ROIC	20.41%	-63.12%

Growth (annualized)

Metric	ETON	STOK
Revenue CAGR (5Y)	47.98%	N/A
Total return CAGR (5Y)	63.04%	-0.24%

Frequently asked

Is ETON or STOK more profitable?: ETON runs the higher net margin — ETON at 12.02% versus STOK at -753.60%.
How have ETON and STOK total returns compared?: Over the past 5 years, ETON delivered 63.04% and STOK delivered -0.24% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ETON analysis Full STOK analysis Interactive comparison tool

Dig into the metrics

Eton Pharmaceuticals P/E ratio Eton Pharmaceuticals ROE Stoke Therapeutics ROE Eton Pharmaceuticals operating margin Stoke Therapeutics operating margin Eton Pharmaceuticals revenue growth Stoke Therapeutics revenue growth Eton Pharmaceuticals free cash flow Stoke Therapeutics free cash flow

Eton Pharmaceuticals & Stoke Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.