Establishment Labs Holdings Inc. (ESTA) vs Palvella Therapeutics, Inc. (PVLA)
A side-by-side comparison of Establishment Labs Holdings Inc. and Palvella Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
ESTA
Establishment Labs Holdings Inc.
$65.33HealthcareDelayed quote: Oct 6, 2026, 1:20 PM EDT
PVLA
Palvella Therapeutics, Inc.
$128.23HealthcareDelayed quote: Oct 6, 2026, 1:15 PM EDT
Total return — ESTA vs PVLA
growth of $100 · dividends reinvested · last 2yESTA +53.6% (+23.9%/yr)PVLA +677.4% (+178.8%/yr)PVLA compounded faster over this window
Log scale — wide-divergence pair
ESTA PVLA
ESTA vs PVLA: by the numbers
- •ESTA is the larger company ($1.92B vs $1.84B market cap).
- •Both run net losses; PVLA's is the smaller (0.00% vs -15.82% net margin).
Metrics side by side
Valuation
| Metric | ESTA | PVLA |
|---|---|---|
| P/S ratio | 7.82 | N/A |
| P/B ratio | 88.98 | 8.48 |
Profitability
| Metric | ESTA | PVLA |
|---|---|---|
| Gross margin | 70.49% | 0.00% |
| Operating margin | -18.48% | 0.00% |
| Net margin | -15.82% | 0.00% |
| ROE | -179.99% | -28.45% |
| ROIC | -6.53% | -23.90% |
Growth (annualized)
| Metric | ESTA | PVLA |
|---|---|---|
| Revenue CAGR (5Y) | 17.02% | N/A |
| Total return CAGR (5Y) | -1.56% | N/A |
Go deeper
Dig into the metrics
Establishment Labs ROEPalvella Therapeutics ROEEstablishment Labs operating marginPalvella Therapeutics operating marginEstablishment Labs revenue growthPalvella Therapeutics revenue growthEstablishment Labs free cash flowPalvella Therapeutics free cash flow
Establishment Labs & Palvella Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.