Design Therapeutics, Inc. (DSGN) vs Gyre Therapeutics, Inc. (GYRE)
A side-by-side comparison of Design Therapeutics, Inc. and Gyre Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
DSGN
Design Therapeutics, Inc.
$11.94HealthcareDelayed quote: Oct 6, 2026, 10:10 AM EDT
GYRE
Gyre Therapeutics, Inc.
$7.25HealthcareDelayed quote: Oct 6, 2026, 10:10 AM EDT
Total return — DSGN vs GYRE
growth of $100 · dividends reinvested · last 6yDSGN -70.1% (-18.2%/yr)GYRE -30.7% (-5.9%/yr)GYRE compounded faster over this window
DSGN GYRE
DSGN vs GYRE: by the numbers
- •GYRE is the larger company ($808M vs $745M market cap).
- •Both run net losses; DSGN's is the smaller (0.00% vs -14.52% net margin).
Metrics side by side
Valuation
| Metric | DSGN | GYRE |
|---|---|---|
| P/S ratio | N/A | 6.77 |
| P/B ratio | 3.69 | 7.49 |
Profitability
| Metric | DSGN | GYRE |
|---|---|---|
| Gross margin | 0.00% | 94.30% |
| Operating margin | 0.00% | 9.86% |
| Net margin | 0.00% | -14.52% |
| ROE | -35.07% | -13.30% |
| ROIC | -38.92% | -9.77% |
Growth (annualized)
| Metric | DSGN | GYRE |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 84.92% |
| Total return CAGR (5Y) | -3.82% | -0.34% |
Frequently asked
- How have DSGN and GYRE total returns compared?
- Over the past 5 years, DSGN delivered -3.82% and GYRE delivered -0.34% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Design Therapeutics ROEGyre Therapeutics ROEDesign Therapeutics operating marginGyre Therapeutics operating marginDesign Therapeutics revenue growthGyre Therapeutics revenue growthDesign Therapeutics free cash flowGyre Therapeutics free cash flow
Design Therapeutics & Gyre Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.