Denali Therapeutics Inc. (DNLI) vs IDEAYA Biosciences, Inc. (IDYA)
A side-by-side comparison of Denali Therapeutics Inc. and IDEAYA Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
DNLI
Denali Therapeutics Inc.
$19.10HealthcareDelayed quote: Oct 6, 2026, 10:25 AM EDT
IDYA
IDEAYA Biosciences, Inc.
$36.67HealthcareDelayed quote: Oct 6, 2026, 10:25 AM EDT
Total return — DNLI vs IDYA
growth of $100 · dividends reinvested · last 7yDNLI -4.1% (-0.6%/yr)IDYA +240.1% (+19.1%/yr)IDYA compounded faster over this window
DNLI IDYA
DNLI vs IDYA: by the numbers
- •IDYA is the larger company ($3.49B vs $3.03B market cap).
- •Both run net losses; IDYA's is the smaller (-74.75% vs -14191.20% net margin).
- •IDYA grew revenue faster over the past five years (45.80% vs 20.68% CAGR).
Metrics side by side
Valuation
| Metric | DNLI | IDYA |
|---|---|---|
| P/S ratio | 841.15 | 14.89 |
| P/B ratio | 3.63 | 2.91 |
Profitability
| Metric | DNLI | IDYA |
|---|---|---|
| Gross margin | 0.00% | -43.89% |
| Operating margin | 0.00% | -72.84% |
| Net margin | -14191.20% | -74.75% |
| ROE | -61.24% | -14.60% |
| ROIC | -50.82% | -17.68% |
Growth (annualized)
| Metric | DNLI | IDYA |
|---|---|---|
| Revenue CAGR (5Y) | 20.68% | 45.80% |
| Total return CAGR (5Y) | -16.91% | 7.32% |
Frequently asked
- Which has grown faster, DNLI or IDYA?
- Over the past five years, IDYA grew revenue faster — DNLI at a 20.68% CAGR versus IDYA at 45.80%.
- How have DNLI and IDYA total returns compared?
- Over the past 5 years, DNLI delivered -16.91% and IDYA delivered 7.32% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Denali Therapeutics ROEIDEAYA Biosciences ROEDenali Therapeutics operating marginIDEAYA Biosciences operating marginDenali Therapeutics revenue growthIDEAYA Biosciences revenue growthDenali Therapeutics free cash flowIDEAYA Biosciences free cash flow
Denali Therapeutics & IDEAYA Biosciences appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.