How have DNLI and DYN total returns compared?

Over the past 5 years, DNLI delivered -16.91% and DYN delivered -0.38% annualized total return. Past performance doesn't predict future results.

Denali Therapeutics Inc. (DNLI) vs Dyne Therapeutics, Inc. (DYN)

A side-by-side comparison of Denali Therapeutics Inc. and Dyne Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

DNLI

Denali Therapeutics Inc.

$3.14B

$19.77HealthcareDelayed quote: Oct 6, 2026, 11:55 AM EDT

DYN

Dyne Therapeutics, Inc.

$2.87B

$15.39HealthcareDelayed quote: Oct 6, 2026, 11:55 AM EDT

Total return — DNLI vs DYN

growth of $100 · dividends reinvested · last 6y

DNLI -47.9% (-10.3%/yr)DYN -35.4% (-7.0%/yr)DYN compounded faster over this window

DNLI DYN

DNLI vs DYN: by the numbers

•DNLI is the larger company ($3.14B vs $2.87B market cap).
•Both run net losses; DYN's is the smaller (0.00% vs -14191.20% net margin).

Metrics side by side

Valuation

Metric	DNLI	DYN
P/S ratio	870.59	N/A
P/B ratio	3.76	4.09

Profitability

Metric	DNLI	DYN
Gross margin	0.00%	0.00%
Operating margin	0.00%	0.00%
Net margin	-14191.20%	0.00%
ROE	-61.24%	-73.97%
ROIC	-50.82%	-58.28%

Growth (annualized)

Metric	DNLI	DYN
Revenue CAGR (5Y)	20.68%	N/A
Total return CAGR (5Y)	-16.91%	-0.38%

Frequently asked

How have DNLI and DYN total returns compared?: Over the past 5 years, DNLI delivered -16.91% and DYN delivered -0.38% annualized total return. Past performance doesn't predict future results.

Go deeper

Full DNLI analysis Full DYN analysis Interactive comparison tool

Dig into the metrics

Denali Therapeutics ROE Dyne Therapeutics ROE Denali Therapeutics operating margin Dyne Therapeutics operating margin Denali Therapeutics revenue growth Dyne Therapeutics revenue growth Denali Therapeutics free cash flow Dyne Therapeutics free cash flow

Denali Therapeutics & Dyne Therapeutics appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.