Is DCTH or MNPR more profitable?

DCTH runs the higher net margin — DCTH at 0.56% versus MNPR at 0.00%.

How have DCTH and MNPR total returns compared?

Over the past 5 years, DCTH delivered 10.90% and MNPR delivered 27.38% annualized total return. Past performance doesn't predict future results.

Delcath Systems, Inc. (DCTH) vs Monopar Therapeutics Inc. (MNPR)

A side-by-side comparison of Delcath Systems, Inc. and Monopar Therapeutics Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

DCTH

Delcath Systems, Inc.

$532M

$15.41HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

MNPR

Monopar Therapeutics Inc.

$533M

$79.57HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — DCTH vs MNPR

growth of $100 · dividends reinvested · last 7y

DCTH -47.3% (-8.7%/yr)MNPR -40.9% (-7.2%/yr)MNPR compounded faster over this window

DCTH MNPR

DCTH vs MNPR: by the numbers

•MNPR is the larger company ($533M vs $532M market cap).
•DCTH is profitable (0.56% net margin) while MNPR runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	DCTH	MNPR
P/E ratio	1185.38	N/A
P/S ratio	5.58	N/A
P/B ratio	4.39	4.07
FCF yield	3.29%	N/A

Profitability

Metric	DCTH	MNPR
Gross margin	87.05%	0.00%
Operating margin	-1.90%	0.00%
Net margin	0.56%	0.00%
ROE	0.44%	-13.64%
ROIC	-0.81%	-16.89%

Growth (annualized)

Metric	DCTH	MNPR
Revenue CAGR (5Y)	118.96%	N/A
Total return CAGR (5Y)	10.90%	27.38%

Frequently asked

Is DCTH or MNPR more profitable?: DCTH runs the higher net margin — DCTH at 0.56% versus MNPR at 0.00%.
How have DCTH and MNPR total returns compared?: Over the past 5 years, DCTH delivered 10.90% and MNPR delivered 27.38% annualized total return. Past performance doesn't predict future results.

Go deeper

Full DCTH analysis Full MNPR analysis Interactive comparison tool

Dig into the metrics

Delcath Systems P/E ratio Delcath Systems ROE Monopar Therapeutics ROE Delcath Systems operating margin Monopar Therapeutics operating margin Delcath Systems revenue growth Monopar Therapeutics revenue growth Delcath Systems free cash flow Monopar Therapeutics free cash flow

Delcath Systems & Monopar Therapeutics appear in these rankings

Fastest Revenue Growth Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.