Which has grown faster, CUE or OPRX?

Over the past five years, CUE grew revenue faster — CUE at a 47.08% CAGR versus OPRX at 13.75%.

Is CUE or OPRX more profitable?

OPRX runs the higher net margin — CUE at -435.83% versus OPRX at 4.66%.

How have CUE and OPRX total returns compared?

Over the past 5 years, CUE delivered -42.42% and OPRX delivered -36.23% annualized total return. Past performance doesn't predict future results.

Cue Biopharma, Inc. (CUE) vs OptimizeRx Corp. (OPRX)

A side-by-side comparison of Cue Biopharma, Inc. and OptimizeRx Corp. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

CUE

Cue Biopharma, Inc.

$171M

$23.54HealthcareDelayed quote: Oct 6, 2026, 2:19 PM EDT

OPRX

OptimizeRx Corp.

$166M

$8.87HealthcareDelayed quote: Oct 6, 2026, 2:19 PM EDT

Total return — CUE vs OPRX

growth of $100 · dividends reinvested · last 9y

CUE -93.0% (-25.6%/yr)OPRX +85.1% (+7.1%/yr)OPRX compounded faster over this window

Log scale — wide-divergence pair

CUE OPRX

CUE vs OPRX: by the numbers

•CUE is the larger company ($171M vs $166M market cap).
•OPRX is profitable (4.66% net margin) while CUE runs a net loss (-435.83%).
•CUE grew revenue faster over the past five years (47.08% vs 13.75% CAGR).

Metrics side by side

Valuation

Metric	CUE	OPRX
P/E ratio	N/A	37.97
Forward P/E	N/A	9.89
P/S ratio	4.54	1.69
P/B ratio	74.03	1.27
EV / EBITDA	N/A	10.48
FCF yield	N/A	11.03%

Profitability

Metric	CUE	OPRX
Gross margin	99.69%	63.30%
Operating margin	-96.56%	11.45%
Net margin	-435.83%	4.66%
ROE	-7104.24%	3.51%
ROIC	-1039.56%	4.92%

Growth (annualized)

Metric	CUE	OPRX
Revenue CAGR (5Y)	47.08%	13.75%
Total return CAGR (5Y)	-42.42%	-36.23%

Frequently asked

Which has grown faster, CUE or OPRX?: Over the past five years, CUE grew revenue faster — CUE at a 47.08% CAGR versus OPRX at 13.75%.
Is CUE or OPRX more profitable?: OPRX runs the higher net margin — CUE at -435.83% versus OPRX at 4.66%.
How have CUE and OPRX total returns compared?: Over the past 5 years, CUE delivered -42.42% and OPRX delivered -36.23% annualized total return. Past performance doesn't predict future results.

Go deeper

Full CUE analysis Full OPRX analysis Interactive comparison tool

Dig into the metrics

OptimizeRx P/E ratio Cue Biopharma ROE OptimizeRx ROE Cue Biopharma operating margin OptimizeRx operating margin Cue Biopharma revenue growth OptimizeRx revenue growth Cue Biopharma free cash flow OptimizeRx free cash flow

Cue Biopharma & OptimizeRx appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.