Which has grown faster, CTMX or IRWD?

Over the past five years, CTMX grew revenue faster — CTMX at a 2.18% CAGR versus IRWD at -1.18%.

Is CTMX or IRWD more profitable?

IRWD runs the higher net margin — CTMX at -435.21% versus IRWD at 33.36%.

How have CTMX and IRWD total returns compared?

Over the past 10 years, CTMX delivered -16.62% and IRWD delivered -13.70% annualized total return. Past performance doesn't predict future results.

CytomX Therapeutics, Inc. (CTMX) vs Ironwood Pharmaceuticals, Inc. (IRWD)

A side-by-side comparison of CytomX Therapeutics, Inc. and Ironwood Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

CTMX

CytomX Therapeutics, Inc.

$557M

$2.56HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

IRWD

Ironwood Pharmaceuticals, Inc.

$598M

$3.63HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — CTMX vs IRWD

growth of $100 · dividends reinvested · last 10y

CTMX -83.3% (-16.4%/yr)IRWD -77.1% (-13.7%/yr)IRWD compounded faster over this window

CTMX IRWD

CTMX vs IRWD: by the numbers

•IRWD is the larger company ($598M vs $557M market cap).
•IRWD is profitable (33.36% net margin) while CTMX runs a net loss (-435.21%).
•CTMX grew revenue faster over the past five years (2.18% vs -1.18% CAGR).

Metrics side by side

Valuation

Metric	CTMX	IRWD
P/E ratio	N/A	4.73
Forward P/E	N/A	2.97
P/S ratio	30.45	1.53
P/B ratio	1.85	N/A
EV / EBITDA	N/A	3.85
FCF yield	N/A	31.05%

Profitability

Metric	CTMX	IRWD
Gross margin	98.63%	99.76%
Operating margin	-29.35%	40.10%
Net margin	-435.21%	33.36%
ROE	-26.37%	N/A
ROIC	-25.42%	58.60%

Growth (annualized)

Metric	CTMX	IRWD
Revenue CAGR (5Y)	2.18%	-1.18%
EPS CAGR (5Y)	N/A	-25.87%
FCF CAGR (5Y)	N/A	-3.98%
Total return CAGR (5Y)	-12.01%	-22.82%

Frequently asked

Which has grown faster, CTMX or IRWD?: Over the past five years, CTMX grew revenue faster — CTMX at a 2.18% CAGR versus IRWD at -1.18%.
Is CTMX or IRWD more profitable?: IRWD runs the higher net margin — CTMX at -435.21% versus IRWD at 33.36%.
How have CTMX and IRWD total returns compared?: Over the past 10 years, CTMX delivered -16.62% and IRWD delivered -13.70% annualized total return. Past performance doesn't predict future results.

Go deeper

Full CTMX analysis Full IRWD analysis Interactive comparison tool

Dig into the metrics

Ironwood Pharmaceuticals P/E ratio CytomX Therapeutics ROE Ironwood Pharmaceuticals ROE CytomX Therapeutics operating margin Ironwood Pharmaceuticals operating margin CytomX Therapeutics revenue growth Ironwood Pharmaceuticals revenue growth CytomX Therapeutics free cash flow Ironwood Pharmaceuticals free cash flow

CytomX Therapeutics & Ironwood Pharmaceuticals appear in these rankings

Highest ROIC Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.