How have CSTL and VOR total returns compared?

Over the past 5 years, CSTL delivered -10.28% and VOR delivered -42.54% annualized total return. Past performance doesn't predict future results.

Castle Biosciences, Inc. (CSTL) vs Vor Biopharma Inc. (VOR)

A side-by-side comparison of Castle Biosciences, Inc. and Vor Biopharma Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

CSTL

Castle Biosciences, Inc.

$1.02B

$33.48HealthcareDelayed quote: Oct 6, 2026, 3:20 PM EDT

VOR

Vor Biopharma Inc.

$998M

$18.43HealthcareDelayed quote: Oct 6, 2026, 3:15 PM EDT

Total return — CSTL vs VOR

growth of $100 · dividends reinvested · last 6y

CSTL -58.4% (-13.6%/yr)VOR -97.5% (-46.0%/yr)CSTL compounded faster over this window

Log scale — wide-divergence pair

CSTL VOR

CSTL vs VOR: by the numbers

•CSTL is the larger company ($1.02B vs $998M market cap).
•Both run net losses; VOR's is the smaller (0.00% vs -5.43% net margin).

Metrics side by side

Valuation

Metric	CSTL	VOR
P/S ratio	2.86	N/A
P/B ratio	2.18	N/A

Profitability

Metric	CSTL	VOR
Gross margin	77.26%	0.00%
Operating margin	-8.99%	0.00%
Net margin	-5.43%	0.00%
ROE	-4.13%	N/A
ROIC	-6.33%	-32.24%

Growth (annualized)

Metric	CSTL	VOR
Revenue CAGR (5Y)	35.55%	N/A
Total return CAGR (5Y)	-10.28%	-42.54%

Frequently asked

How have CSTL and VOR total returns compared?: Over the past 5 years, CSTL delivered -10.28% and VOR delivered -42.54% annualized total return. Past performance doesn't predict future results.

Go deeper

Full CSTL analysis Full VOR analysis Interactive comparison tool

Dig into the metrics

Castle Biosciences ROE Vor Biopharma ROE Castle Biosciences operating margin Vor Biopharma operating margin Castle Biosciences revenue growth Vor Biopharma revenue growth Castle Biosciences free cash flow Vor Biopharma free cash flow

Castle Biosciences & Vor Biopharma appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.