Castle Biosciences, Inc. (CSTL) vs Janux Therapeutics, Inc. (JANX)
A side-by-side comparison of Castle Biosciences, Inc. and Janux Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CSTL
Castle Biosciences, Inc.
$34.10HealthcareDelayed quote: Oct 6, 2026, 11:50 AM EDT
JANX
Janux Therapeutics, Inc.
$17.28HealthcareDelayed quote: Oct 6, 2026, 11:45 AM EDT
Total return — CSTL vs JANX
growth of $100 · dividends reinvested · last 5yCSTL -49.0% (-12.6%/yr)JANX -34.2% (-8.0%/yr)JANX compounded faster over this window
CSTL JANX
CSTL vs JANX: by the numbers
- •JANX is the larger company ($1.05B vs $1.04B market cap).
- •Both run net losses; CSTL's is the smaller (-5.43% vs -321.81% net margin).
- •JANX grew revenue faster over the past five years (105.89% vs 35.55% CAGR).
Metrics side by side
Valuation
| Metric | CSTL | JANX |
|---|---|---|
| P/S ratio | 2.92 | 33.05 |
| P/B ratio | 2.22 | 1.14 |
Profitability
| Metric | CSTL | JANX |
|---|---|---|
| Gross margin | 77.26% | 79.71% |
| Operating margin | -8.99% | -1576.67% |
| Net margin | -5.43% | -321.81% |
| ROE | -4.13% | -11.06% |
| ROIC | -6.33% | -15.15% |
Growth (annualized)
| Metric | CSTL | JANX |
|---|---|---|
| Revenue CAGR (5Y) | 35.55% | 105.89% |
| Total return CAGR (5Y) | -10.28% | -6.45% |
Frequently asked
- Which has grown faster, CSTL or JANX?
- Over the past five years, JANX grew revenue faster — CSTL at a 35.55% CAGR versus JANX at 105.89%.
- How have CSTL and JANX total returns compared?
- Over the past 5 years, CSTL delivered -10.28% and JANX delivered -6.45% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Castle Biosciences ROEJanux Therapeutics ROECastle Biosciences operating marginJanux Therapeutics operating marginCastle Biosciences revenue growthJanux Therapeutics revenue growthCastle Biosciences free cash flowJanux Therapeutics free cash flow
Castle Biosciences & Janux Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.