Castle Biosciences, Inc. (CSTL) vs Integra LifeSciences Holdings Corporation (IART)
A side-by-side comparison of Castle Biosciences, Inc. and Integra LifeSciences Holdings Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CSTL
Castle Biosciences, Inc.
$36.29HealthcareDelayed quote: Oct 6, 2026, 10:05 AM EDT
IART
Integra LifeSciences Holdings Corporation
$12.92HealthcareDelayed quote: Oct 6, 2026, 10:05 AM EDT
Total return — CSTL vs IART
growth of $100 · dividends reinvested · last 7yCSTL +71.3% (+8.0%/yr)IART -79.0% (-20.0%/yr)CSTL compounded faster over this window
Log scale — wide-divergence pair
CSTL IART
CSTL vs IART: by the numbers
- •CSTL is the larger company ($1.11B vs $1.00B market cap).
- •Both run net losses; IART's is the smaller (-0.44% vs -5.43% net margin).
- •CSTL grew revenue faster over the past five years (35.55% vs 1.77% CAGR).
Metrics side by side
Valuation
| Metric | CSTL | IART |
|---|---|---|
| Forward P/E | N/A | 5.29 |
| P/S ratio | 3.10 | 0.61 |
| P/B ratio | 2.36 | 0.96 |
| EV / EBITDA | N/A | 3.50 |
Profitability
| Metric | CSTL | IART |
|---|---|---|
| Gross margin | 77.26% | 53.74% |
| Operating margin | -8.99% | 4.18% |
| Net margin | -5.43% | -0.44% |
| ROE | -4.13% | -0.69% |
| ROIC | -6.33% | 20.01% |
Growth (annualized)
| Metric | CSTL | IART |
|---|---|---|
| Revenue CAGR (5Y) | 35.55% | 1.77% |
| Total return CAGR (5Y) | -10.28% | -28.16% |
Frequently asked
- Which has grown faster, CSTL or IART?
- Over the past five years, CSTL grew revenue faster — CSTL at a 35.55% CAGR versus IART at 1.77%.
- How have CSTL and IART total returns compared?
- Over the past 5 years, CSTL delivered -10.28% and IART delivered -28.16% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Castle Biosciences ROEIntegra LifeSciences ROECastle Biosciences operating marginIntegra LifeSciences operating marginCastle Biosciences revenue growthIntegra LifeSciences revenue growthCastle Biosciences free cash flowIntegra LifeSciences free cash flow
Castle Biosciences & Integra LifeSciences appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.