CRISPR Therapeutics AG (CRSP) vs Kiniksa Pharmaceuticals International, plc (KNSA)
A side-by-side comparison of CRISPR Therapeutics AG and Kiniksa Pharmaceuticals International, plc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CRSP
CRISPR Therapeutics AG
$54.03HealthcareDelayed quote: Oct 6, 2026, 12:15 PM EDT
KNSA
Kiniksa Pharmaceuticals International, plc
$75.69HealthcareDelayed quote: Oct 6, 2026, 12:15 PM EDT
Total return — CRSP vs KNSA
growth of $100 · dividends reinvested · last 8yCRSP -10.1% (-1.3%/yr)KNSA +291.9% (+18.6%/yr)KNSA compounded faster over this window
CRSP KNSA
CRSP vs KNSA: by the numbers
- •KNSA is the larger company ($5.77B vs $5.21B market cap).
- •KNSA is profitable (9.59% net margin) while CRSP runs a net loss (-3368.72%).
- •KNSA grew revenue faster over the past five years (155.66% vs 37.32% CAGR).
Metrics side by side
Valuation
| Metric | CRSP | KNSA |
|---|---|---|
| P/E ratio | N/A | 77.23 |
| Forward P/E | N/A | 54.34 |
| P/S ratio | 389.12 | 6.86 |
| P/B ratio | 2.98 | 8.82 |
| EV / EBITDA | N/A | 54.89 |
| FCF yield | N/A | 3.17% |
Profitability
| Metric | CRSP | KNSA |
|---|---|---|
| Gross margin | -6537.01% | 54.49% |
| Operating margin | -16191.40% | 11.92% |
| Net margin | -3368.72% | 9.59% |
| ROE | -25.83% | 12.33% |
| ROIC | -21.12% | 9.76% |
Growth (annualized)
| Metric | CRSP | KNSA |
|---|---|---|
| Revenue CAGR (5Y) | 37.32% | 155.66% |
| Total return CAGR (5Y) | -10.97% | 47.48% |
Frequently asked
- Which has grown faster, CRSP or KNSA?
- Over the past five years, KNSA grew revenue faster — CRSP at a 37.32% CAGR versus KNSA at 155.66%.
- Is CRSP or KNSA more profitable?
- KNSA runs the higher net margin — CRSP at -3368.72% versus KNSA at 9.59%.
- How have CRSP and KNSA total returns compared?
- Over the past 5 years, CRSP delivered -10.97% and KNSA delivered 47.48% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Kiniksa Pharmaceuticals International P/E ratioCRISPR Therapeutics AG ROEKiniksa Pharmaceuticals International ROECRISPR Therapeutics AG operating marginKiniksa Pharmaceuticals International operating marginCRISPR Therapeutics AG revenue growthKiniksa Pharmaceuticals International revenue growthCRISPR Therapeutics AG free cash flowKiniksa Pharmaceuticals International free cash flow
CRISPR Therapeutics AG & Kiniksa Pharmaceuticals International appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.