Charles River Laboratories International, Inc. (CRL) vs 23andMe Holding Co. (ME)
CRL leads on 6 of 9 compared metrics.
A side-by-side comparison of Charles River Laboratories International, Inc. and 23andMe Holding Co. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 13, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
CRL
Charles River Laboratories International, Inc.
$187.51Healthcare
ME
23andMe Holding Co.
$0.61Healthcare
Total return — CRL vs ME
growth of $100 · last 5yCRL -20.5%ME -99.7%CRL compounded faster
Log scale — wide-divergence pair
CRL ME
CRL vs ME: by the numbers
- •CRL is the larger company ($9.03B vs $15M market cap).
- •Both run net losses; CRL's is the smaller (-4.59% vs -134.54% net margin).
- •CRL grew revenue faster over the past five years (5.77% vs -9.07% CAGR).
Which is better, CRL or ME?
Metric tally: CRL 6 · ME 3It depends on what you're optimizing for:
GrowthCRL(faster 5Y revenue CAGR)
QualityCRL(higher ROIC)
Valuation
| Metric | CRL | ME |
|---|---|---|
| Forward P/E | 15.21 | — |
| P/S ratio | 2.28 | 0.10● |
| P/B ratio | 3.12 | 0.51● |
| EV / EBITDA | 41.45 | — |
| FCF yield | 4.26% | — |
Profitability
| Metric | CRL | ME |
|---|---|---|
| Gross margin | 31.86% | 53.33%● |
| Operating margin | 11.77%● | -114.00% |
| Net margin | -4.59%● | -134.54% |
| ROE | -6.28%● | -721.75% |
| ROIC | 8.36%● | -553.10% |
Growth (annualized)
| Metric | CRL | ME |
|---|---|---|
| Revenue CAGR (5Y) | 5.77%● | -9.07% |
| EPS CAGR (5Y) | -40.99% | — |
| FCF CAGR (5Y) | -3.98% | — |
| Total return CAGR (5Y) | -11.83%● | -68.93% |
Frequently asked
- Which is better, CRL or ME?
- It depends on your goal. growth: CRL (faster 5Y revenue CAGR); quality: CRL (higher ROIC). Across all compared metrics, CRL leads 6 to 3.
- Which has grown faster, CRL or ME?
- Over the past five years, CRL grew revenue faster — CRL at a 5.77% CAGR versus ME at -9.07%.
- Which has been the better investment, CRL or ME?
- Over the past 5-year, CRL delivered the higher annualized total return — CRL at 8.26% versus ME at -68.93%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Charles River Laboratories International P/E ratio23andMe P/E ratioCharles River Laboratories International dividend yield23andMe dividend yieldCharles River Laboratories International ROE23andMe ROECharles River Laboratories International operating margin23andMe operating marginCharles River Laboratories International revenue growth23andMe revenue growthCharles River Laboratories International free cash flow23andMe free cash flow
Charles River Laboratories International & 23andMe appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 13, 2026.