Which has the lower trailing P/E, COO or EXEL?

EXEL has the lower trailing P/E: COO trades at 64.54 and EXEL at 16.95. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, COO or EXEL?

Over the past five years, EXEL grew revenue faster — COO at a 9.73% CAGR versus EXEL at 16.06%.

Is COO or EXEL more profitable?

EXEL runs the higher net margin — COO at 5.57% versus EXEL at 35.33%.

How have COO and EXEL total returns compared?

Over the past 10 years, COO delivered 5.19% and EXEL delivered 17.26% annualized total return. Past performance doesn't predict future results.

The Cooper Companies, Inc. (COO) vs Exelixis, Inc. (EXEL)

A side-by-side comparison of The Cooper Companies, Inc. and Exelixis, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 21, 2026. Differences are shown without an overall score or investment verdict.

COO

The Cooper Companies, Inc.

$14.87B

$76.22HealthcareDelayed quote: Aug 21, 2026, 4:00 PM EDT

EXEL

Exelixis, Inc.

$13.59B

$54.08HealthcareDelayed quote: Aug 21, 2026, 4:00 PM EDT

Total return — COO vs EXEL

growth of $100 · dividends reinvested · last 10y

COO +65.9% (+5.2%/yr)EXEL +384.7% (+17.1%/yr)EXEL compounded faster over this window

COO EXEL

COO vs EXEL: by the numbers

•COO is the larger company ($14.87B vs $13.59B market cap).
•EXEL trades at the lower trailing earnings multiple (16.95 vs 64.54 P/E), one valuation lens rather than an overall verdict.
•EXEL converts more revenue to profit (35.33% vs 5.57% net margin).
•EXEL grew revenue faster over the past five years (16.06% vs 9.73% CAGR).

Metrics side by side

Valuation

Metric	COO	EXEL
P/E ratio	64.54	16.95
Forward P/E	16.44	18.14
P/S ratio	3.51	5.77
P/B ratio	1.80	7.62
EV / EBITDA	19.46	13.93
FCF yield	3.83%	8.41%

Profitability

Metric	COO	EXEL
Gross margin	64.37%	96.48%
Operating margin	11.77%	39.88%
Net margin	5.57%	35.33%
ROE	2.86%	46.68%
ROIC	2.52%	37.87%

Growth (annualized)

Metric	COO	EXEL
Revenue CAGR (5Y)	9.73%	16.06%
EPS CAGR (5Y)	-17.30%	51.51%
FCF CAGR (5Y)	6.61%	40.17%
Total return CAGR (5Y)	-7.26%	24.00%

Frequently asked

Which has the lower trailing P/E, COO or EXEL?: EXEL has the lower trailing P/E: COO trades at 64.54 and EXEL at 16.95. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, COO or EXEL?: Over the past five years, EXEL grew revenue faster — COO at a 9.73% CAGR versus EXEL at 16.06%.
Is COO or EXEL more profitable?: EXEL runs the higher net margin — COO at 5.57% versus EXEL at 35.33%.
How have COO and EXEL total returns compared?: Over the past 10 years, COO delivered 5.19% and EXEL delivered 17.26% annualized total return. Past performance doesn't predict future results.

Go deeper

Full COO analysis Full EXEL analysis Interactive comparison tool

Dig into the metrics

Cooper Companies P/E ratio Exelixis P/E ratio Cooper Companies ROE Exelixis ROE Cooper Companies operating margin Exelixis operating margin Cooper Companies revenue growth Exelixis revenue growth Cooper Companies free cash flow Exelixis free cash flow

Cooper Companies & Exelixis appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 21, 2026.