Which has grown faster, COLL or WVE?

Over the past five years, WVE grew revenue faster — COLL at a 19.91% CAGR versus WVE at 33.08%.

Is COLL or WVE more profitable?

COLL runs the higher net margin — COLL at 5.93% versus WVE at -309.73%.

How have COLL and WVE total returns compared?

Over the past 10 years, COLL delivered 1.39% and WVE delivered -19.53% annualized total return. Past performance doesn't predict future results.

Collegium Pharmaceutical, Inc. (COLL) vs Wave Life Sciences Ltd. (WVE)

A side-by-side comparison of Collegium Pharmaceutical, Inc. and Wave Life Sciences Ltd. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

COLL

Collegium Pharmaceutical, Inc.

$710M

$21.88HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

WVE

Wave Life Sciences Ltd.

$694M

$3.52HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — COLL vs WVE

growth of $100 · dividends reinvested · last 10y

COLL +14.8% (+1.4%/yr)WVE -88.1% (-19.2%/yr)COLL compounded faster over this window

Log scale — wide-divergence pair

COLL WVE

COLL vs WVE: by the numbers

•COLL is the larger company ($710M vs $694M market cap).
•COLL is profitable (5.93% net margin) while WVE runs a net loss (-309.73%).
•WVE grew revenue faster over the past five years (33.08% vs 19.91% CAGR).

Metrics side by side

Valuation

Metric	COLL	WVE
P/E ratio	17.65	N/A
PEG ratio	0.99	N/A
P/S ratio	0.88	10.61
P/B ratio	2.28	1.53
EV / EBITDA	2.84	N/A
FCF yield	46.26%	N/A

Profitability

Metric	COLL	WVE
Gross margin	60.02%	79.28%
Operating margin	19.61%	-504.09%
Net margin	5.93%	-309.73%
ROE	15.36%	-44.64%
ROIC	6.11%	-42.94%

Growth (annualized)

Metric	COLL	WVE
Revenue CAGR (5Y)	19.91%	33.08%
EPS CAGR (5Y)	20.48%	N/A
FCF CAGR (5Y)	26.38%	N/A
Total return CAGR (5Y)	2.15%	-4.33%

Frequently asked

Which has grown faster, COLL or WVE?: Over the past five years, WVE grew revenue faster — COLL at a 19.91% CAGR versus WVE at 33.08%.
Is COLL or WVE more profitable?: COLL runs the higher net margin — COLL at 5.93% versus WVE at -309.73%.
How have COLL and WVE total returns compared?: Over the past 10 years, COLL delivered 1.39% and WVE delivered -19.53% annualized total return. Past performance doesn't predict future results.

Go deeper

Full COLL analysis Full WVE analysis Interactive comparison tool

Dig into the metrics

Collegium Pharmaceutical P/E ratio Collegium Pharmaceutical ROE Wave Life Sciences ROE Collegium Pharmaceutical operating margin Wave Life Sciences operating margin Collegium Pharmaceutical revenue growth Wave Life Sciences revenue growth Collegium Pharmaceutical free cash flow Wave Life Sciences free cash flow

Collegium Pharmaceutical & Wave Life Sciences appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.