Is COGT or SHC more profitable?

SHC runs the higher net margin — COGT at 0.00% versus SHC at 13.44%.

How have COGT and SHC total returns compared?

Over the past 5 years, COGT delivered 28.51% and SHC delivered -6.39% annualized total return. Past performance doesn't predict future results.

Cogent Biosciences, Inc. (COGT) vs Sotera Health Company (SHC)

A side-by-side comparison of Cogent Biosciences, Inc. and Sotera Health Company across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

COGT

Cogent Biosciences, Inc.

$5.19B

$30.38HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

SHC

Sotera Health Company

$5.20B

$18.25HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — COGT vs SHC

growth of $100 · dividends reinvested · last 6y

COGT +206.9% (+20.5%/yr)SHC -26.1% (-4.9%/yr)COGT compounded faster over this window

COGT SHC

COGT vs SHC: by the numbers

•SHC is the larger company ($5.20B vs $5.19B market cap).
•SHC is profitable (13.44% net margin) while COGT runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	COGT	SHC
P/E ratio	N/A	31.88
Forward P/E	N/A	18.53
P/S ratio	N/A	4.28
P/B ratio	11.10	7.82
EV / EBITDA	N/A	12.43
FCF yield	N/A	2.17%

Profitability

Metric	COGT	SHC
Gross margin	0.00%	54.72%
Operating margin	0.00%	36.24%
Net margin	0.00%	13.44%
ROE	-70.85%	24.56%
ROIC	-50.09%	8.80%

Growth (annualized)

Metric	COGT	SHC
Revenue CAGR (5Y)	N/A	6.66%
FCF CAGR (5Y)	N/A	17.34%
Total return CAGR (5Y)	28.51%	-6.39%

Frequently asked

Is COGT or SHC more profitable?: SHC runs the higher net margin — COGT at 0.00% versus SHC at 13.44%.
How have COGT and SHC total returns compared?: Over the past 5 years, COGT delivered 28.51% and SHC delivered -6.39% annualized total return. Past performance doesn't predict future results.

Go deeper

Full COGT analysis Full SHC analysis Interactive comparison tool

Dig into the metrics

Sotera Health P/E ratio Cogent Biosciences ROE Sotera Health ROE Cogent Biosciences operating margin Sotera Health operating margin Cogent Biosciences revenue growth Sotera Health revenue growth Cogent Biosciences free cash flow Sotera Health free cash flow

Cogent Biosciences & Sotera Health appear in these rankings

Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.