Celldex Therapeutics, Inc. (CLDX) vs Harmony Biosciences Holdings, Inc. (HRMY)
A side-by-side comparison of Celldex Therapeutics, Inc. and Harmony Biosciences Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CLDX
Celldex Therapeutics, Inc.
$30.99HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT
HRMY
Harmony Biosciences Holdings, Inc.
$39.37HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT
Total return — CLDX vs HRMY
growth of $100 · dividends reinvested · last 6yCLDX +204.9% (+20.4%/yr)HRMY +7.9% (+1.3%/yr)CLDX compounded faster over this window
CLDX HRMY
CLDX vs HRMY: by the numbers
- •HRMY is the larger company ($2.28B vs $2.06B market cap).
- •HRMY is profitable (18.88% net margin) while CLDX runs a net loss (-268385.71%).
- •HRMY grew revenue faster over the past five years (32.47% vs -58.05% CAGR).
Metrics side by side
Valuation
| Metric | CLDX | HRMY |
|---|---|---|
| P/E ratio | N/A | 12.78 |
| Forward P/E | N/A | 9.99 |
| P/S ratio | 18413.09 | 2.37 |
| P/B ratio | 2.89 | 2.28 |
| EV / EBITDA | N/A | 7.36 |
| FCF yield | N/A | 15.57% |
Profitability
| Metric | CLDX | HRMY |
|---|---|---|
| Gross margin | 100.00% | 75.42% |
| Operating margin | -19160.00% | 24.03% |
| Net margin | -268385.71% | 18.88% |
| ROE | -42.07% | 18.14% |
| ROIC | -45.19% | 14.96% |
Growth (annualized)
| Metric | CLDX | HRMY |
|---|---|---|
| Revenue CAGR (5Y) | -58.05% | 32.47% |
| FCF CAGR (5Y) | N/A | 48.43% |
| Total return CAGR (5Y) | -10.28% | 0.91% |
Frequently asked
- Which has grown faster, CLDX or HRMY?
- Over the past five years, HRMY grew revenue faster — CLDX at a -58.05% CAGR versus HRMY at 32.47%.
- Is CLDX or HRMY more profitable?
- HRMY runs the higher net margin — CLDX at -268385.71% versus HRMY at 18.88%.
- How have CLDX and HRMY total returns compared?
- Over the past 5 years, CLDX delivered -10.28% and HRMY delivered 0.91% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Harmony Biosciences P/E ratioCelldex Therapeutics ROEHarmony Biosciences ROECelldex Therapeutics operating marginHarmony Biosciences operating marginCelldex Therapeutics revenue growthHarmony Biosciences revenue growthCelldex Therapeutics free cash flowHarmony Biosciences free cash flow
Celldex Therapeutics & Harmony Biosciences appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.