Cigna Corporation (CI) vs Vertex Pharmaceuticals Incorporated (VRTX)
VRTX leads on 9 of 16 compared metrics, though CI is the cheaper stock.
A side-by-side comparison of Cigna Corporation and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 15, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
CI
Cigna Corporation
$298.00Healthcare
VRTX
Vertex Pharmaceuticals Incorporated
$444.93Healthcare
Total return — CI vs VRTX
growth of $100 · last 30yCI +2291.7%VRTX +2424.4%VRTX compounded faster
CI VRTX
CI vs VRTX: by the numbers
- •VRTX is the larger company ($112.92B vs $78.83B market cap).
- •CI trades at the lower earnings multiple (12.64 vs 26.39 P/E).
- •VRTX converts more revenue to profit (35.40% vs 2.26% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 11.28% CAGR).
- •CI pays a dividend (2.06% yield) while VRTX does not currently pay one.
Which is better, CI or VRTX?
Metric tally: CI 7 · VRTX 9It depends on what you're optimizing for:
ValueCI(lower P/E)
GrowthVRTX(faster 5Y revenue CAGR)
QualityVRTX(higher ROIC)
Metrics side by side
Valuation
| Metric | CI | VRTX |
|---|---|---|
| P/E ratio | 12.64● | 26.39 |
| Forward P/E | 8.91● | 20.58 |
| P/S ratio | 0.28● | 9.31 |
| P/B ratio | 1.87● | 5.89 |
| PEG ratio | 0.15● | 3.23 |
| EV / EBITDA | 8.41● | 20.72 |
| FCF yield | 9.73%● | 3.25% |
Profitability
| Metric | CI | VRTX |
|---|---|---|
| Gross margin | 9.30% | 86.28%● |
| Operating margin | 3.42% | 38.97%● |
| Net margin | 2.26% | 35.40%● |
| ROE | 14.90% | 22.41%● |
| ROIC | 7.35% | 18.12%● |
Dividends
| Metric | CI | VRTX |
|---|---|---|
| Dividend yield | 2.06% | — |
| Payout ratio | 27.53% | — |
Growth (annualized)
| Metric | CI | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 11.28% | 13.82%● |
| EPS CAGR (5Y) | -0.76% | 8.17%● |
| FCF CAGR (5Y) | -2.03% | 4.01%● |
| Total return CAGR (5Y) | 6.19% | 18.17%● |
Frequently asked
- Which is better, CI or VRTX?
- It depends on your goal. value: CI (lower P/E); growth: VRTX (faster 5Y revenue CAGR); quality: VRTX (higher ROIC). Across all compared metrics, VRTX leads 9 to 7.
- Is CI or VRTX cheaper?
- On trailing earnings, CI is cheaper: CI trades at a 12.64 P/E and VRTX at 26.39.
- Which has grown faster, CI or VRTX?
- Over the past five years, VRTX grew revenue faster — CI at a 11.28% CAGR versus VRTX at 13.82%.
- Does CI or VRTX pay a bigger dividend?
- CI pays a dividend (2.06% yield) while VRTX does not currently pay one.
- Is CI or VRTX more profitable?
- VRTX runs the higher net margin — CI at 2.26% versus VRTX at 35.40%.
- Which has been the better investment, CI or VRTX?
- Over the past 10-year, VRTX delivered the higher annualized total return — CI at 9.91% versus VRTX at 17.13%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Cigna P/E ratioVertex Pharmaceuticals P/E ratioCigna dividend yieldVertex Pharmaceuticals dividend yieldCigna ROEVertex Pharmaceuticals ROECigna operating marginVertex Pharmaceuticals operating marginCigna revenue growthVertex Pharmaceuticals revenue growthCigna free cash flowVertex Pharmaceuticals free cash flow
Cigna & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 15, 2026.