Is CDNA or PLSE more profitable?

CDNA runs the higher net margin — CDNA at 24.23% versus PLSE at -6755.78%.

How have CDNA and PLSE total returns compared?

Over the past 10 years, CDNA delivered 34.41% and PLSE delivered 23.22% annualized total return. Past performance doesn't predict future results.

CareDx, Inc (CDNA) vs Pulse Biosciences, Inc. (PLSE)

A side-by-side comparison of CareDx, Inc and Pulse Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

CDNA

CareDx, Inc

$3.34B

$64.63HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

PLSE

Pulse Biosciences, Inc.

$3.41B

$49.30HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

Total return — CDNA vs PLSE

growth of $100 · dividends reinvested · last 10y

CDNA +1824.2% (+34.4%/yr)PLSE +700.3% (+23.1%/yr)CDNA compounded faster over this window

CDNA PLSE

CDNA vs PLSE: by the numbers

•PLSE is the larger company ($3.41B vs $3.34B market cap).
•CDNA is profitable (24.23% net margin) while PLSE runs a net loss (-6755.78%).

Metrics side by side

Valuation

Metric	CDNA	PLSE
P/E ratio	31.20	N/A
Forward P/E	53.95	N/A
P/S ratio	7.30	2879.36
P/B ratio	7.86	34.29
EV / EBITDA	192.12	N/A
FCF yield	2.54%	N/A

Profitability

Metric	CDNA	PLSE
Gross margin	70.58%	-360.00%
Operating margin	-0.92%	-21982.57%
Net margin	24.23%	-6755.78%
ROE	26.08%	-80.46%
ROIC	-0.93%	-79.40%

Growth (annualized)

Metric	CDNA	PLSE
Revenue CAGR (5Y)	12.56%	N/A
Total return CAGR (5Y)	1.33%	19.76%

Frequently asked

Is CDNA or PLSE more profitable?: CDNA runs the higher net margin — CDNA at 24.23% versus PLSE at -6755.78%.
How have CDNA and PLSE total returns compared?: Over the past 10 years, CDNA delivered 34.41% and PLSE delivered 23.22% annualized total return. Past performance doesn't predict future results.

Go deeper

Full CDNA analysis Full PLSE analysis Interactive comparison tool

Dig into the metrics

CareDx P/E ratio CareDx ROE Pulse Biosciences ROE CareDx operating margin Pulse Biosciences operating margin CareDx revenue growth Pulse Biosciences revenue growth CareDx free cash flow Pulse Biosciences free cash flow

CareDx & Pulse Biosciences appear in these rankings

Highest ROE Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.