Which has the lower trailing P/E, BIO or KRYS?

KRYS has the lower trailing P/E: BIO trades at 44.90 and KRYS at 41.26. P/E is one valuation measure and does not by itself establish which business is cheaper.

Is BIO or KRYS more profitable?

KRYS runs the higher net margin — BIO at 8.59% versus KRYS at 54.82%.

How have BIO and KRYS total returns compared?

Over the past 5 years, BIO delivered -12.10% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Bio-Rad Laboratories, Inc. (BIO) vs Krystal Biotech, Inc. (KRYS)

A side-by-side comparison of Bio-Rad Laboratories, Inc. and Krystal Biotech, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

BIO

Bio-Rad Laboratories, Inc.

$9.97B

$370.43HealthcareDelayed quote: Oct 6, 2026, 12:34 PM EDT

KRYS

Krystal Biotech, Inc.

$9.71B

$329.24HealthcareDelayed quote: Oct 6, 2026, 12:30 PM EDT

Total return — BIO vs KRYS

growth of $100 · dividends reinvested · last 9y

BIO +72.3% (+6.2%/yr)KRYS +3047.1% (+46.7%/yr)KRYS compounded faster over this window

Log scale — wide-divergence pair

BIO KRYS

BIO vs KRYS: by the numbers

•BIO is the larger company ($9.97B vs $9.71B market cap).
•KRYS trades at the lower trailing earnings multiple (41.26 vs 44.90 P/E), one valuation lens rather than an overall verdict.
•KRYS converts more revenue to profit (54.82% vs 8.59% net margin).

Metrics side by side

Valuation

Metric	BIO	KRYS
P/E ratio	44.90	41.26
Forward P/E	38.00	43.28
P/S ratio	3.85	22.03
P/B ratio	1.39	7.14
EV / EBITDA	27.86	45.44
FCF yield	3.54%	2.66%

Profitability

Metric	BIO	KRYS
Gross margin	51.90%	93.34%
Operating margin	9.08%	44.93%
Net margin	8.59%	54.82%
ROE	3.10%	17.77%
ROIC	1.54%	14.41%

Growth (annualized)

Metric	BIO	KRYS
Revenue CAGR (5Y)	0.29%	N/A
EPS CAGR (5Y)	-26.27%	N/A
FCF CAGR (5Y)	-9.65%	N/A
Total return CAGR (5Y)	-12.10%	44.28%

Frequently asked

Which has the lower trailing P/E, BIO or KRYS?: KRYS has the lower trailing P/E: BIO trades at 44.90 and KRYS at 41.26. P/E is one valuation measure and does not by itself establish which business is cheaper.
Is BIO or KRYS more profitable?: KRYS runs the higher net margin — BIO at 8.59% versus KRYS at 54.82%.
How have BIO and KRYS total returns compared?: Over the past 5 years, BIO delivered -12.10% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Go deeper

Full BIO analysis Full KRYS analysis Interactive comparison tool

Dig into the metrics

Bio-Rad Laboratories P/E ratio Krystal Biotech P/E ratio Bio-Rad Laboratories ROE Krystal Biotech ROE Bio-Rad Laboratories operating margin Krystal Biotech operating margin Bio-Rad Laboratories revenue growth Krystal Biotech revenue growth Bio-Rad Laboratories free cash flow Krystal Biotech free cash flow

Bio-Rad Laboratories & Krystal Biotech appear in these rankings

Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.