Which has the lower trailing P/E, BIIB or ILMN?

BIIB has the lower trailing P/E: BIIB trades at 38.92 and ILMN at 50.94. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, BIIB or ILMN?

Over the past five years, ILMN grew revenue faster — BIIB at a -3.19% CAGR versus ILMN at 5.04%.

Is BIIB or ILMN more profitable?

ILMN runs the higher net margin — BIIB at 8.39% versus ILMN at 18.36%.

How have BIIB and ILMN total returns compared?

Over the past 10 years, BIIB delivered -3.34% and ILMN delivered 4.17% annualized total return. Past performance doesn't predict future results.

Biogen Inc. (BIIB) vs Illumina, Inc. (ILMN)

A side-by-side comparison of Biogen Inc. and Illumina, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 2, 2026. Differences are shown without an overall score or investment verdict.

BIIB

Biogen Inc.

$32.49B

$219.88HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

ILMN

Illumina, Inc.

$41.31B

$273.04HealthcareDelayed quote: Oct 2, 2026, 4:00 PM EDT

Total return — BIIB vs ILMN

growth of $100 · dividends reinvested · last 10y

BIIB -27.1% (-3.1%/yr)ILMN +48.2% (+4.0%/yr)ILMN compounded faster over this window

BIIB ILMN

BIIB vs ILMN: by the numbers

•ILMN is the larger company ($41.31B vs $32.49B market cap).
•BIIB trades at the lower trailing earnings multiple (38.92 vs 50.94 P/E), one valuation lens rather than an overall verdict.
•ILMN converts more revenue to profit (18.36% vs 8.39% net margin).
•ILMN grew revenue faster over the past five years (5.04% vs -3.19% CAGR).

Metrics side by side

Valuation

Metric	BIIB	ILMN
P/E ratio	38.92	50.94
Forward P/E	17.71	51.00
PEG ratio	N/A	11.99
P/S ratio	3.27	9.19
P/B ratio	1.72	14.56
EV / EBITDA	N/A	35.22
FCF yield	8.30%	2.27%

Profitability

Metric	BIIB	ILMN
Gross margin	67.71%	66.79%
Operating margin	12.79%	20.97%
Net margin	8.39%	18.36%
ROE	4.43%	29.07%
ROIC	4.28%	13.74%

Growth (annualized)

Metric	BIIB	ILMN
Revenue CAGR (5Y)	-3.19%	5.04%
EPS CAGR (5Y)	-18.67%	4.22%
FCF CAGR (5Y)	-11.63%	1.03%
Total return CAGR (5Y)	-4.73%	-7.09%

Frequently asked

Which has the lower trailing P/E, BIIB or ILMN?: BIIB has the lower trailing P/E: BIIB trades at 38.92 and ILMN at 50.94. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, BIIB or ILMN?: Over the past five years, ILMN grew revenue faster — BIIB at a -3.19% CAGR versus ILMN at 5.04%.
Is BIIB or ILMN more profitable?: ILMN runs the higher net margin — BIIB at 8.39% versus ILMN at 18.36%.
How have BIIB and ILMN total returns compared?: Over the past 10 years, BIIB delivered -3.34% and ILMN delivered 4.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full BIIB analysis Full ILMN analysis Interactive comparison tool

Dig into the metrics

Biogen P/E ratio Illumina P/E ratio Biogen ROE Illumina ROE Biogen operating margin Illumina operating margin Biogen revenue growth Illumina revenue growth Biogen free cash flow Illumina free cash flow

Biogen & Illumina appear in these rankings

Highest ROE Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 2, 2026.