Biofrontera Inc. (BFRI) vs SeaStar Medical Holding Corporation (ICU)
A side-by-side comparison of Biofrontera Inc. and SeaStar Medical Holding Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
BFRI
Biofrontera Inc.
$0.89HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
ICU
SeaStar Medical Holding Corporation
$3.55HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
Total return — BFRI vs ICU
growth of $100 · dividends reinvested · last 4yBFRI -94.9% (-52.5%/yr)ICU -99.9% (-80.7%/yr)BFRI compounded faster over this window
Log scale — wide-divergence pair
BFRI ICU
BFRI vs ICU: by the numbers
- •BFRI is the larger company ($11M vs $10M market cap).
- •Both run net losses; BFRI's is the smaller (-13.78% vs -795.50% net margin).
Metrics side by side
Valuation
| Metric | BFRI | ICU |
|---|---|---|
| P/S ratio | 0.25 | 5.88 |
| P/B ratio | 1.92 | 2.35 |
Profitability
| Metric | BFRI | ICU |
|---|---|---|
| Gross margin | 84.45% | 92.64% |
| Operating margin | -21.94% | -986.63% |
| Net margin | -13.78% | -795.50% |
| ROE | -106.87% | -317.20% |
| ROIC | -32.27% | -325.63% |
Growth (annualized)
| Metric | BFRI | ICU |
|---|---|---|
| Revenue CAGR (5Y) | 15.55% | N/A |
Go deeper
Dig into the metrics
Biofrontera ROESeaStar Medical ROEBiofrontera operating marginSeaStar Medical operating marginBiofrontera revenue growthSeaStar Medical revenue growthBiofrontera free cash flowSeaStar Medical free cash flow
Biofrontera & SeaStar Medical appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.