BioCryst Pharmaceuticals, Inc. (BCRX) vs Harmony Biosciences Holdings, Inc. (HRMY)
A side-by-side comparison of BioCryst Pharmaceuticals, Inc. and Harmony Biosciences Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
BCRX
BioCryst Pharmaceuticals, Inc.
$8.08HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT
HRMY
Harmony Biosciences Holdings, Inc.
$39.94HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT
Total return — BCRX vs HRMY
growth of $100 · dividends reinvested · last 6yBCRX +96.1% (+11.9%/yr)HRMY +7.9% (+1.3%/yr)BCRX compounded faster over this window
BCRX HRMY
BCRX vs HRMY: by the numbers
- •HRMY is the larger company ($2.31B vs $2.05B market cap).
- •HRMY is profitable (18.88% net margin) while BCRX runs a net loss (-40.90%).
- •BCRX grew revenue faster over the past five years (64.07% vs 32.47% CAGR).
Metrics side by side
Valuation
| Metric | BCRX | HRMY |
|---|---|---|
| P/E ratio | N/A | 12.97 |
| Forward P/E | N/A | 10.13 |
| P/S ratio | 2.18 | 2.41 |
| P/B ratio | N/A | 2.31 |
| EV / EBITDA | N/A | 7.49 |
| FCF yield | 17.39% | 15.35% |
Profitability
| Metric | BCRX | HRMY |
|---|---|---|
| Gross margin | 97.82% | 75.42% |
| Operating margin | 38.98% | 24.03% |
| Net margin | -40.90% | 18.88% |
| ROE | N/A | 18.14% |
| ROIC | -89.73% | 14.96% |
Growth (annualized)
| Metric | BCRX | HRMY |
|---|---|---|
| Revenue CAGR (5Y) | 64.07% | 32.47% |
| FCF CAGR (5Y) | N/A | 48.43% |
| Total return CAGR (5Y) | -10.02% | 0.91% |
Frequently asked
- Which has grown faster, BCRX or HRMY?
- Over the past five years, BCRX grew revenue faster — BCRX at a 64.07% CAGR versus HRMY at 32.47%.
- Is BCRX or HRMY more profitable?
- HRMY runs the higher net margin — BCRX at -40.90% versus HRMY at 18.88%.
- How have BCRX and HRMY total returns compared?
- Over the past 5 years, BCRX delivered -10.02% and HRMY delivered 0.91% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Harmony Biosciences P/E ratioBioCryst Pharmaceuticals ROEHarmony Biosciences ROEBioCryst Pharmaceuticals operating marginHarmony Biosciences operating marginBioCryst Pharmaceuticals revenue growthHarmony Biosciences revenue growthBioCryst Pharmaceuticals free cash flowHarmony Biosciences free cash flow
BioCryst Pharmaceuticals & Harmony Biosciences appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.