AstraZeneca PLC (AZN) vs Roche Holding AG (RHHBY)
A side-by-side comparison of AstraZeneca PLC and Roche Holding AG across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 27, 2026. Differences are shown without an overall score or investment verdict.
AZN
AstraZeneca PLC
$164.52HealthcareDelayed quote: Aug 27, 2026, 4:00 PM EDT
RHHBY
Roche Holding AG
$56.39HealthcareDelayed quote: Aug 27, 2026, 4:00 PM EDT
Total return — AZN vs RHHBY
growth of $100 · dividends reinvested · last 10yAZN +222.8% (+12.4%/yr)RHHBY +158.1% (+9.9%/yr)AZN compounded faster over this window
AZN RHHBY
AZN vs RHHBY: by the numbers
- •RHHBY is the larger company ($359.46B vs $255.15B market cap).
- •RHHBY trades at the lower trailing earnings multiple (16.15 vs 24.97 P/E), one valuation lens rather than an overall verdict.
- •RHHBY converts more revenue to profit (20.33% vs 17.02% net margin).
- •AZN grew revenue faster over the past five years (15.76% vs 3.94% CAGR).
- •RHHBY pays the higher dividend yield (2.75% vs 0.64%).
Metrics side by side
Valuation
| Metric | AZN | RHHBY |
|---|---|---|
| P/E ratio | 24.97 | 16.15 |
| Forward P/E | 16.24 | 22.83 |
| P/S ratio | 4.23 | 4.53 |
| P/B ratio | 5.16 | 9.06 |
| EV / EBITDA | 14.10 | 14.21 |
| FCF yield | 3.37% | 4.69% |
Profitability
| Metric | AZN | RHHBY |
|---|---|---|
| Gross margin | 81.88% | 73.73% |
| Operating margin | 22.77% | 29.16% |
| Net margin | 17.02% | 20.33% |
| ROE | 20.79% | 38.06% |
| ROIC | 12.83% | 19.71% |
Dividends
| Metric | AZN | RHHBY |
|---|---|---|
| Dividend yield | 0.64% | 2.75% |
| Payout ratio | 16.06% | 60.81% |
Growth (annualized)
| Metric | AZN | RHHBY |
|---|---|---|
| Revenue CAGR (5Y) | 15.76% | 3.94% |
| EPS CAGR (5Y) | 22.02% | 1.54% |
| FCF CAGR (5Y) | 14.53% | 5.54% |
| Total return CAGR (5Y) | 9.31% | 5.84% |
Frequently asked
- Which has the lower trailing P/E, AZN or RHHBY?
- RHHBY has the lower trailing P/E: AZN trades at 24.97 and RHHBY at 16.15. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, AZN or RHHBY?
- Over the past five years, AZN grew revenue faster — AZN at a 15.76% CAGR versus RHHBY at 3.94%.
- Does AZN or RHHBY pay a bigger dividend?
- AZN yields 0.64% and RHHBY yields 2.75% based on trailing dividends and the latest price.
- Is AZN or RHHBY more profitable?
- RHHBY runs the higher net margin — AZN at 17.02% versus RHHBY at 20.33%.
- How have AZN and RHHBY total returns compared?
- Over the past 10 years, AZN delivered 12.70% and RHHBY delivered 9.59% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
AstraZeneca P/E ratioRoche Holding AG P/E ratioAstraZeneca dividend yieldRoche Holding AG dividend yieldAstraZeneca ROERoche Holding AG ROEAstraZeneca operating marginRoche Holding AG operating marginAstraZeneca revenue growthRoche Holding AG revenue growthAstraZeneca free cash flowRoche Holding AG free cash flow
AstraZeneca & Roche Holding AG appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 27, 2026.