AstraZeneca PLC (AZN) vs Pfizer Inc. (PFE)

A side-by-side comparison of AstraZeneca PLC and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.

Compare

Total returnAZN vs PFE

growth of $100 · dividends reinvested · last 30y
AZN +2029.9%PFE +543.3%AZN compounded faster
05001k2k2k3kStart $100200120062011201620212026$2,130$643
AZN PFE

AZN vs PFE: by the numbers

  • PFE is the larger company ($143.91B vs $133.67B market cap).
  • AZN trades at the lower trailing earnings multiple (12.77 vs 18.83 P/E), one valuation lens rather than an overall verdict.
  • AZN converts more revenue to profit (17.19% vs 11.83% net margin).
  • AZN grew revenue faster over the past five years (16.99% vs 8.22% CAGR).
  • PFE pays the higher dividend yield (6.97% vs 1.89%).

Metrics side by side

Valuation

MetricAZNPFE
P/E ratio12.7718.83
Forward P/E16.588.38
P/S ratio2.192.23
P/B ratio2.801.57
PEG ratio0.29N/A
EV / EBITDA7.899.72
FCF yield6.09%6.71%

Profitability

MetricAZNPFE
Gross margin81.68%69.35%
Operating margin23.69%23.45%
Net margin17.19%11.83%
ROE21.95%8.31%
ROIC13.03%8.84%

Dividends

MetricAZNPFE
Dividend yield1.89%6.97%
Payout ratio24.24%126.47%

Growth (annualized)

MetricAZNPFE
Revenue CAGR (5Y)16.99%8.22%
EPS CAGR (5Y)22.02%-3.78%
FCF CAGR (5Y)15.68%-3.79%
Total return CAGR (5Y)10.56%-5.21%

Frequently asked

Which has the lower trailing P/E, AZN or PFE?
AZN has the lower trailing P/E: AZN trades at 12.77 and PFE at 18.83. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, AZN or PFE?
Over the past five years, AZN grew revenue faster — AZN at a 16.99% CAGR versus PFE at 8.22%.
Does AZN or PFE pay a bigger dividend?
AZN yields 1.89% and PFE yields 6.97% based on trailing dividends and the latest price.
Is AZN or PFE more profitable?
AZN runs the higher net margin — AZN at 17.19% versus PFE at 11.83%.
How have AZN and PFE total returns compared?
Over the past 10 years, AZN delivered 13.96% and PFE delivered 1.55% annualized total return. Past performance doesn't predict future results.

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.