AstraZeneca PLC (AZN) vs Pfizer Inc. (PFE)
A side-by-side comparison of AstraZeneca PLC and Pfizer Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.
AZN
AstraZeneca PLC
$172.48HealthcareDelayed quote: Jul 28, 2026, 7:53 PM EDT
PFE
Pfizer Inc.
$25.25HealthcareDelayed quote: Jul 28, 2026, 4:02 PM EDT
Total return — AZN vs PFE
growth of $100 · dividends reinvested · last 30yAZN +2029.9%PFE +543.3%AZN compounded faster
AZN PFE
AZN vs PFE: by the numbers
- •PFE is the larger company ($143.91B vs $133.67B market cap).
- •AZN trades at the lower trailing earnings multiple (12.77 vs 18.83 P/E), one valuation lens rather than an overall verdict.
- •AZN converts more revenue to profit (17.19% vs 11.83% net margin).
- •AZN grew revenue faster over the past five years (16.99% vs 8.22% CAGR).
- •PFE pays the higher dividend yield (6.97% vs 1.89%).
Metrics side by side
Valuation
| Metric | AZN | PFE |
|---|---|---|
| P/E ratio | 12.77 | 18.83 |
| Forward P/E | 16.58 | 8.38 |
| P/S ratio | 2.19 | 2.23 |
| P/B ratio | 2.80 | 1.57 |
| PEG ratio | 0.29 | N/A |
| EV / EBITDA | 7.89 | 9.72 |
| FCF yield | 6.09% | 6.71% |
Profitability
| Metric | AZN | PFE |
|---|---|---|
| Gross margin | 81.68% | 69.35% |
| Operating margin | 23.69% | 23.45% |
| Net margin | 17.19% | 11.83% |
| ROE | 21.95% | 8.31% |
| ROIC | 13.03% | 8.84% |
Dividends
| Metric | AZN | PFE |
|---|---|---|
| Dividend yield | 1.89% | 6.97% |
| Payout ratio | 24.24% | 126.47% |
Growth (annualized)
| Metric | AZN | PFE |
|---|---|---|
| Revenue CAGR (5Y) | 16.99% | 8.22% |
| EPS CAGR (5Y) | 22.02% | -3.78% |
| FCF CAGR (5Y) | 15.68% | -3.79% |
| Total return CAGR (5Y) | 10.56% | -5.21% |
Frequently asked
- Which has the lower trailing P/E, AZN or PFE?
- AZN has the lower trailing P/E: AZN trades at 12.77 and PFE at 18.83. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, AZN or PFE?
- Over the past five years, AZN grew revenue faster — AZN at a 16.99% CAGR versus PFE at 8.22%.
- Does AZN or PFE pay a bigger dividend?
- AZN yields 1.89% and PFE yields 6.97% based on trailing dividends and the latest price.
- Is AZN or PFE more profitable?
- AZN runs the higher net margin — AZN at 17.19% versus PFE at 11.83%.
- How have AZN and PFE total returns compared?
- Over the past 10 years, AZN delivered 13.96% and PFE delivered 1.55% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
AstraZeneca P/E ratioPfizer P/E ratioAstraZeneca dividend yieldPfizer dividend yieldAstraZeneca ROEPfizer ROEAstraZeneca operating marginPfizer operating marginAstraZeneca revenue growthPfizer revenue growthAstraZeneca free cash flowPfizer free cash flow
AstraZeneca & Pfizer appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.