AstraZeneca PLC (AZN) vs Merck & Co., Inc. (MRK)
A side-by-side comparison of AstraZeneca PLC and Merck & Co., Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.
AZN
AstraZeneca PLC
$172.48HealthcareDelayed quote: Jul 28, 2026, 7:53 PM EDT
MRK
Merck & Co., Inc.
$131.84HealthcareDelayed quote: Jul 28, 2026, 3:59 PM EDT
Total return — AZN vs MRK
growth of $100 · dividends reinvested · last 30yAZN +2029.9%MRK +990.2%AZN compounded faster
AZN MRK
AZN vs MRK: by the numbers
- •MRK is the larger company ($325.61B vs $133.67B market cap).
- •AZN trades at the lower trailing earnings multiple (12.77 vs 36.83 P/E), one valuation lens rather than an overall verdict.
- •AZN converts more revenue to profit (17.19% vs 13.62% net margin).
- •AZN grew revenue faster over the past five years (16.99% vs 8.60% CAGR).
- •MRK pays the higher dividend yield (2.57% vs 1.89%).
Metrics side by side
Valuation
| Metric | AZN | MRK |
|---|---|---|
| P/E ratio | 12.77 | 36.83 |
| Forward P/E | 16.58 | 47.09 |
| P/S ratio | 2.19 | 4.93 |
| P/B ratio | 2.80 | 7.05 |
| PEG ratio | 0.29 | 1.81 |
| EV / EBITDA | 7.89 | 15.16 |
| FCF yield | 6.09% | 4.37% |
Profitability
| Metric | AZN | MRK |
|---|---|---|
| Gross margin | 81.68% | 75.91% |
| Operating margin | 23.69% | 36.17% |
| Net margin | 17.19% | 13.62% |
| ROE | 21.95% | 19.48% |
| ROIC | 13.03% | 18.27% |
Dividends
| Metric | AZN | MRK |
|---|---|---|
| Dividend yield | 1.89% | 2.57% |
| Payout ratio | 24.24% | 46.03% |
Growth (annualized)
| Metric | AZN | MRK |
|---|---|---|
| Revenue CAGR (5Y) | 16.99% | 8.60% |
| EPS CAGR (5Y) | 22.02% | 21.21% |
| FCF CAGR (5Y) | 15.68% | 15.69% |
| Total return CAGR (5Y) | 10.56% | 14.44% |
Frequently asked
- Which has the lower trailing P/E, AZN or MRK?
- AZN has the lower trailing P/E: AZN trades at 12.77 and MRK at 36.83. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, AZN or MRK?
- Over the past five years, AZN grew revenue faster — AZN at a 16.99% CAGR versus MRK at 8.60%.
- Does AZN or MRK pay a bigger dividend?
- AZN yields 1.89% and MRK yields 2.57% based on trailing dividends and the latest price.
- Is AZN or MRK more profitable?
- AZN runs the higher net margin — AZN at 17.19% versus MRK at 13.62%.
- How have AZN and MRK total returns compared?
- Over the past 10 years, AZN delivered 13.96% and MRK delivered 12.27% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
AstraZeneca P/E ratioMerck & P/E ratioAstraZeneca dividend yieldMerck & dividend yieldAstraZeneca ROEMerck & ROEAstraZeneca operating marginMerck & operating marginAstraZeneca revenue growthMerck & revenue growthAstraZeneca free cash flowMerck & free cash flow
AstraZeneca & Merck & appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.