AstraZeneca PLC (AZN) vs Merck & Co., Inc. (MRK)

A side-by-side comparison of AstraZeneca PLC and Merck & Co., Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.

Compare

Total returnAZN vs MRK

growth of $100 · dividends reinvested · last 30y
AZN +2029.9%MRK +990.2%AZN compounded faster
05001k2k2k3kStart $100200120062011201620212026$2,130$1,090
AZN MRK

AZN vs MRK: by the numbers

  • MRK is the larger company ($325.61B vs $133.67B market cap).
  • AZN trades at the lower trailing earnings multiple (12.77 vs 36.83 P/E), one valuation lens rather than an overall verdict.
  • AZN converts more revenue to profit (17.19% vs 13.62% net margin).
  • AZN grew revenue faster over the past five years (16.99% vs 8.60% CAGR).
  • MRK pays the higher dividend yield (2.57% vs 1.89%).

Metrics side by side

Valuation

MetricAZNMRK
P/E ratio12.7736.83
Forward P/E16.5847.09
P/S ratio2.194.93
P/B ratio2.807.05
PEG ratio0.291.81
EV / EBITDA7.8915.16
FCF yield6.09%4.37%

Profitability

MetricAZNMRK
Gross margin81.68%75.91%
Operating margin23.69%36.17%
Net margin17.19%13.62%
ROE21.95%19.48%
ROIC13.03%18.27%

Dividends

MetricAZNMRK
Dividend yield1.89%2.57%
Payout ratio24.24%46.03%

Growth (annualized)

MetricAZNMRK
Revenue CAGR (5Y)16.99%8.60%
EPS CAGR (5Y)22.02%21.21%
FCF CAGR (5Y)15.68%15.69%
Total return CAGR (5Y)10.56%14.44%

Frequently asked

Which has the lower trailing P/E, AZN or MRK?
AZN has the lower trailing P/E: AZN trades at 12.77 and MRK at 36.83. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, AZN or MRK?
Over the past five years, AZN grew revenue faster — AZN at a 16.99% CAGR versus MRK at 8.60%.
Does AZN or MRK pay a bigger dividend?
AZN yields 1.89% and MRK yields 2.57% based on trailing dividends and the latest price.
Is AZN or MRK more profitable?
AZN runs the higher net margin — AZN at 17.19% versus MRK at 13.62%.
How have AZN and MRK total returns compared?
Over the past 10 years, AZN delivered 13.96% and MRK delivered 12.27% annualized total return. Past performance doesn't predict future results.

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.