AstraZeneca PLC (AZN) vs Intuitive Surgical, Inc. (ISRG)

AZN leads on 11 of 16 compared metrics.

A side-by-side comparison of AstraZeneca PLC and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 14, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

AstraZeneca PLC logo
AZN
AstraZeneca PLC
$277.22B
$178.75Healthcare
Intuitive Surgical, Inc. logo
ISRG
Intuitive Surgical, Inc.
$145.58B
$411.06Healthcare

Total return — AZN vs ISRG

growth of $100 · last 26y
AZN +329.4%ISRG +20149.3%ISRG compounded faster
Log scale — wide-divergence pair
101001k10k100kStart $10020052010201520202025$429$20,249
AZN ISRG

AZN vs ISRG: by the numbers

  • •AZN is the larger company ($277.22B vs $145.58B market cap).
  • •AZN trades at the lower earnings multiple (26.92 vs 49.83 P/E).
  • •ISRG converts more revenue to profit (28.15% vs 17.19% net margin).
  • •ISRG grew revenue faster over the past five years (18.39% vs 16.99% CAGR).
  • •AZN pays a dividend (1.79% yield) while ISRG does not currently pay one.

Which is better, AZN or ISRG?

Metric tally: AZN 11 · ISRG 5

It depends on what you're optimizing for:

ValueAZN(lower P/E)
GrowthISRG(faster 5Y revenue CAGR)
QualityISRG(higher ROIC)

Valuation

MetricAZNISRG
P/E ratio26.92●49.83
Forward P/E15.33●34.71
P/S ratio4.62●13.98
P/B ratio5.90●8.46
PEG ratio0.14●3.17
EV / EBITDA14.92●35.41
FCF yield2.89%●1.92%

Profitability

MetricAZNISRG
Gross margin81.68%●66.29%
Operating margin23.69%30.45%●
Net margin17.19%28.15%●
ROE21.95%●17.05%
ROIC13.03%13.71%●

Dividends

MetricAZNISRG
Dividend yield1.79%—
Payout ratio48.48%—

Growth (annualized)

MetricAZNISRG
Revenue CAGR (5Y)16.99%18.39%●
EPS CAGR (5Y)22.02%●21.51%
FCF CAGR (5Y)15.68%16.61%●
Total return CAGR (5Y)11.03%●7.37%

Frequently asked

Which is better, AZN or ISRG?
It depends on your goal. value: AZN (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: ISRG (higher ROIC). Across all compared metrics, AZN leads 11 to 5.
Is AZN or ISRG cheaper?
On trailing earnings, AZN is cheaper: AZN trades at a 26.92 P/E and ISRG at 49.83.
Which has grown faster, AZN or ISRG?
Over the past five years, ISRG grew revenue faster — AZN at a 16.99% CAGR versus ISRG at 18.39%.
Does AZN or ISRG pay a bigger dividend?
AZN pays a dividend (1.79% yield) while ISRG does not currently pay one.
Is AZN or ISRG more profitable?
ISRG runs the higher net margin — AZN at 17.19% versus ISRG at 28.15%.
Which has been the better investment, AZN or ISRG?
Over the past 10-year, ISRG delivered the higher annualized total return — AZN at 15.77% versus ISRG at 19.14%. Past performance doesn't predict future results.

Go deeper

Full AZN analysisFull ISRG analysisInteractive comparison tool

Dig into the metrics

AstraZeneca P/E ratioIntuitive Surgical P/E ratioAstraZeneca dividend yieldIntuitive Surgical dividend yieldAstraZeneca ROEIntuitive Surgical ROEAstraZeneca operating marginIntuitive Surgical operating marginAstraZeneca revenue growthIntuitive Surgical revenue growthAstraZeneca free cash flowIntuitive Surgical free cash flow

AstraZeneca & Intuitive Surgical appear in these rankings

Fastest Revenue Growth StocksHighest Operating Margin StocksBest 10-Year Total Return StocksLargest Companies by Market Cap

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 14, 2026.