AstraZeneca PLC (AZN) vs Intuitive Surgical, Inc. (ISRG)
A side-by-side comparison of AstraZeneca PLC and Intuitive Surgical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 29, 2026. Differences are shown without an overall score or investment verdict.
AZN
AstraZeneca PLC
$173.30HealthcareDelayed quote: Jul 29, 2026, 4:00 PM EDT
ISRG
Intuitive Surgical, Inc.
$353.10HealthcareDelayed quote: Jul 29, 2026, 4:00 PM EDT
Total return — AZN vs ISRG
growth of $100 · dividends reinvested · last 26yAZN +943.2%ISRG +17722.7%ISRG compounded faster
Log scale — wide-divergence pair
AZN ISRG
AZN vs ISRG: by the numbers
- •AZN is the larger company ($134.31B vs $124.74B market cap).
- •AZN trades at the lower trailing earnings multiple (12.99 vs 41.16 P/E), one valuation lens rather than an overall verdict.
- •ISRG converts more revenue to profit (28.45% vs 17.19% net margin).
- •AZN grew revenue faster over the past five years (16.99% vs 16.41% CAGR).
- •AZN pays a dividend (1.86% yield), while ISRG has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | AZN | ISRG |
|---|---|---|
| P/E ratio | 12.99 | 41.16 |
| Forward P/E | 16.82 | 33.60 |
| P/S ratio | 2.23 | 11.75 |
| P/B ratio | 2.84 | 7.14 |
| PEG ratio | 0.29 | 3.17 |
| EV / EBITDA | 8.00 | 30.00 |
| FCF yield | 6.00% | 2.48% |
Profitability
| Metric | AZN | ISRG |
|---|---|---|
| Gross margin | 81.68% | 66.68% |
| Operating margin | 23.69% | 31.28% |
| Net margin | 17.19% | 28.45% |
| ROE | 21.95% | 17.28% |
| ROIC | 13.03% | 13.71% |
Dividends
| Metric | AZN | ISRG |
|---|---|---|
| Dividend yield | 1.86% | N/A |
| Payout ratio | 24.24% | N/A |
Growth (annualized)
| Metric | AZN | ISRG |
|---|---|---|
| Revenue CAGR (5Y) | 16.99% | 16.41% |
| EPS CAGR (5Y) | 22.02% | 21.51% |
| FCF CAGR (5Y) | 15.68% | 14.17% |
| Total return CAGR (5Y) | 10.67% | 2.22% |
Frequently asked
- Which has the lower trailing P/E, AZN or ISRG?
- AZN has the lower trailing P/E: AZN trades at 12.99 and ISRG at 41.16. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, AZN or ISRG?
- Over the past five years, AZN grew revenue faster — AZN at a 16.99% CAGR versus ISRG at 16.41%.
- Does AZN or ISRG pay a bigger dividend?
- AZN pays a dividend (1.86% yield), while ISRG has no payments in the available dividend history.
- Is AZN or ISRG more profitable?
- ISRG runs the higher net margin — AZN at 17.19% versus ISRG at 28.45%.
- How have AZN and ISRG total returns compared?
- Over the past 10 years, AZN delivered 13.18% and ISRG delivered 16.79% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
AstraZeneca P/E ratioIntuitive Surgical P/E ratioAstraZeneca dividend yieldIntuitive Surgical dividend yieldAstraZeneca ROEIntuitive Surgical ROEAstraZeneca operating marginIntuitive Surgical operating marginAstraZeneca revenue growthIntuitive Surgical revenue growthAstraZeneca free cash flowIntuitive Surgical free cash flow
AstraZeneca & Intuitive Surgical appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 29, 2026.