Aytu BioPharma, Inc. (AYTU) vs TherapeuticsMD, Inc. (TXMD)
A side-by-side comparison of Aytu BioPharma, Inc. and TherapeuticsMD, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
AYTU
Aytu BioPharma, Inc.
$2.05HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
TXMD
TherapeuticsMD, Inc.
$2.02HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — AYTU vs TXMD
growth of $100 · dividends reinvested · last 10yAYTU -100.0% (-68.9%/yr)TXMD -99.4% (-40.0%/yr)TXMD compounded faster over this window
Log scale — wide-divergence pair
AYTU TXMD
AYTU vs TXMD: by the numbers
- •TXMD is the larger company ($23M vs $22M market cap).
- •Both run net losses; TXMD's is the smaller (-6.64% vs -24.76% net margin).
- •Both shrank revenue over the past five years; AYTU's decline was smaller (-2.59% vs -47.86% CAGR).
Metrics side by side
Valuation
| Metric | AYTU | TXMD |
|---|---|---|
| Forward P/E | N/A | 11.88 |
| P/S ratio | 0.38 | 7.15 |
| P/B ratio | 0.62 | 0.86 |
| FCF yield | 14.78% | 13.34% |
Profitability
| Metric | AYTU | TXMD |
|---|---|---|
| Gross margin | 63.95% | 100.00% |
| Operating margin | -14.44% | -139.44% |
| Net margin | -24.76% | -6.64% |
| ROE | -40.40% | -0.80% |
| ROIC | -14.21% | -11.84% |
Growth (annualized)
| Metric | AYTU | TXMD |
|---|---|---|
| Revenue CAGR (5Y) | -2.59% | -47.86% |
| Total return CAGR (5Y) | -48.14% | -44.16% |
Frequently asked
- Which has grown faster, AYTU or TXMD?
- Neither grew: over the past five years both shrank revenue, with AYTU's decline the smaller — AYTU at a -2.59% CAGR versus TXMD at -47.86%.
- How have AYTU and TXMD total returns compared?
- Over the past 10 years, AYTU delivered -68.87% and TXMD delivered -40.05% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Aytu BioPharma ROETherapeuticsMD ROEAytu BioPharma operating marginTherapeuticsMD operating marginAytu BioPharma revenue growthTherapeuticsMD revenue growthAytu BioPharma free cash flowTherapeuticsMD free cash flow
Aytu BioPharma & TherapeuticsMD appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.