How have AYTU and LONA total returns compared?

Over the past 5 years, AYTU delivered -48.14% and LONA delivered -43.13% annualized total return. Past performance doesn't predict future results.

Aytu BioPharma, Inc. (AYTU) vs LeonaBio, Inc. (LONA)

A side-by-side comparison of Aytu BioPharma, Inc. and LeonaBio, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AYTU

Aytu BioPharma, Inc.

$22M

$2.04HealthcareDelayed quote: Oct 6, 2026, 10:39 AM EDT

LONA

LeonaBio, Inc.

$23M

$5.74HealthcareDelayed quote: Oct 6, 2026, 10:37 AM EDT

Total return — AYTU vs LONA

growth of $100 · dividends reinvested · last 6y

AYTU -99.2% (-55.1%/yr)LONA -96.7% (-43.5%/yr)LONA compounded faster over this window

AYTU LONA

AYTU vs LONA: by the numbers

•LONA is the larger company ($23M vs $22M market cap).
•Both run net losses; LONA's is the smaller (0.00% vs -24.76% net margin).

Metrics side by side

Valuation

Metric	AYTU	LONA
P/S ratio	0.38	N/A
P/B ratio	0.62	0.67
FCF yield	14.85%	N/A

Profitability

Metric	AYTU	LONA
Gross margin	63.95%	0.00%
Operating margin	-14.44%	0.00%
Net margin	-24.76%	0.00%
ROE	-40.40%	-421.06%
ROIC	-14.21%	-248.21%

Growth (annualized)

Metric	AYTU	LONA
Revenue CAGR (5Y)	-2.59%	N/A
Total return CAGR (5Y)	-48.14%	-43.13%

Frequently asked

How have AYTU and LONA total returns compared?: Over the past 5 years, AYTU delivered -48.14% and LONA delivered -43.13% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AYTU analysis Full LONA analysis Interactive comparison tool

Dig into the metrics

Aytu BioPharma ROE LeonaBio ROE Aytu BioPharma operating margin LeonaBio operating margin Aytu BioPharma revenue growth LeonaBio revenue growth Aytu BioPharma free cash flow LeonaBio free cash flow

Aytu BioPharma & LeonaBio appear in these rankings

Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.