Aytu BioPharma, Inc. (AYTU) vs Dyadic International, Inc. (DYAI)
A side-by-side comparison of Aytu BioPharma, Inc. and Dyadic International, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
AYTU
Aytu BioPharma, Inc.
$2.07HealthcareDelayed quote: Oct 6, 2026, 11:22 AM EDT
DYAI
Dyadic International, Inc.
$0.46HealthcareDelayed quote: Oct 6, 2026, 11:21 AM EDT
Total return — AYTU vs DYAI
growth of $100 · dividends reinvested · last 10yAYTU -100.0% (-68.5%/yr)DYAI -70.5% (-11.5%/yr)DYAI compounded faster over this window
Log scale — wide-divergence pair
AYTU DYAI
AYTU vs DYAI: by the numbers
- •AYTU is the larger company ($22M vs $17M market cap).
- •Both run net losses; AYTU's is the smaller (-24.76% vs -219.50% net margin).
- •Both shrank revenue over the past five years; AYTU's decline was smaller (-2.59% vs -5.11% CAGR).
Metrics side by side
Valuation
| Metric | AYTU | DYAI |
|---|---|---|
| P/S ratio | 0.39 | 4.77 |
| P/B ratio | 0.63 | N/A |
| FCF yield | 14.64% | N/A |
Profitability
| Metric | AYTU | DYAI |
|---|---|---|
| Gross margin | 63.95% | -88.25% |
| Operating margin | -14.44% | -579.88% |
| Net margin | -24.76% | -219.50% |
| ROE | -40.40% | N/A |
| ROIC | -14.21% | -279.48% |
Growth (annualized)
| Metric | AYTU | DYAI |
|---|---|---|
| Revenue CAGR (5Y) | -2.59% | -5.11% |
| Total return CAGR (5Y) | -48.14% | -38.53% |
Frequently asked
- Which has grown faster, AYTU or DYAI?
- Neither grew: over the past five years both shrank revenue, with AYTU's decline the smaller — AYTU at a -2.59% CAGR versus DYAI at -5.11%.
- How have AYTU and DYAI total returns compared?
- Over the past 10 years, AYTU delivered -68.87% and DYAI delivered -11.56% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Aytu BioPharma ROEDyadic International ROEAytu BioPharma operating marginDyadic International operating marginAytu BioPharma revenue growthDyadic International revenue growthAytu BioPharma free cash flowDyadic International free cash flow
Aytu BioPharma & Dyadic International appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.