Avalo Therapeutics, Inc. (AVTX) vs Gyre Therapeutics, Inc. (GYRE)
A side-by-side comparison of Avalo Therapeutics, Inc. and Gyre Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
AVTX
Avalo Therapeutics, Inc.
$13.74HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT
GYRE
Gyre Therapeutics, Inc.
$7.20HealthcareDelayed quote: Oct 6, 2026, 12:00 PM EDT
Total return — AVTX vs GYRE
growth of $100 · dividends reinvested · last 10yAVTX -99.9% (-48.7%/yr)GYRE -80.3% (-15.0%/yr)GYRE compounded faster over this window
Log scale — wide-divergence pair
AVTX GYRE
AVTX vs GYRE: by the numbers
- •GYRE is the larger company ($802M vs $722M market cap).
- •Both run net losses; GYRE's is the smaller (-14.52% vs -170055.93% net margin).
- •GYRE grew revenue faster over the past five years (84.92% vs -60.88% CAGR).
Metrics side by side
Valuation
| Metric | AVTX | GYRE |
|---|---|---|
| P/S ratio | 12237.90 | 6.72 |
| P/B ratio | 1.61 | 7.43 |
Profitability
| Metric | AVTX | GYRE |
|---|---|---|
| Gross margin | 100.00% | 94.30% |
| Operating margin | -123601.69% | 9.86% |
| Net margin | -170055.93% | -14.52% |
| ROE | -22.36% | -13.30% |
| ROIC | -19.45% | -9.77% |
Growth (annualized)
| Metric | AVTX | GYRE |
|---|---|---|
| Revenue CAGR (5Y) | -60.88% | 84.92% |
| Total return CAGR (5Y) | -70.04% | -0.34% |
Frequently asked
- Which has grown faster, AVTX or GYRE?
- Over the past five years, GYRE grew revenue faster — AVTX at a -60.88% CAGR versus GYRE at 84.92%.
- How have AVTX and GYRE total returns compared?
- Over the past 10 years, AVTX delivered -48.70% and GYRE delivered -14.92% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Avalo Therapeutics ROEGyre Therapeutics ROEAvalo Therapeutics operating marginGyre Therapeutics operating marginAvalo Therapeutics revenue growthGyre Therapeutics revenue growthAvalo Therapeutics free cash flowGyre Therapeutics free cash flow
Avalo Therapeutics & Gyre Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.