Alphatec Holdings, Inc. (ATEC) vs Septerna Inc (SEPN)

A side-by-side comparison of Alphatec Holdings, Inc. and Septerna Inc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ATEC

Alphatec Holdings, Inc.

$1.65B

$10.71HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT

SEPN

Septerna Inc

$1.65B

$36.61HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT

Total return — ATEC vs SEPN

growth of $100 · dividends reinvested · last 2y

ATEC +89.1% (+37.5%/yr)SEPN +77.0% (+33.0%/yr)ATEC compounded faster over this window

ATEC SEPN

ATEC vs SEPN: by the numbers

•SEPN is the larger company ($1.65B vs $1.65B market cap).
•Both run net losses; ATEC's is the smaller (-13.50% vs -24.51% net margin).

Metrics side by side

Valuation

Metric	ATEC	SEPN
Forward P/E	32.77	N/A
P/S ratio	2.02	16.69
P/B ratio	N/A	4.27
EV / EBITDA	57.33	N/A
FCF yield	0.25%	6.37%

Profitability

Metric	ATEC	SEPN
Gross margin	66.15%	99.57%
Operating margin	-5.55%	-175.83%
Net margin	-13.50%	-24.51%
ROE	N/A	-6.27%
ROIC	-7.32%	-8.93%

Growth (annualized)

Metric	ATEC	SEPN
Revenue CAGR (5Y)	33.61%	N/A
Total return CAGR (5Y)	-2.26%	N/A

Go deeper

Full ATEC analysis Full SEPN analysis Interactive comparison tool

Dig into the metrics

Alphatec ROE Septerna ROE Alphatec operating margin Septerna operating margin Alphatec revenue growth Septerna revenue growth Alphatec free cash flow Septerna free cash flow

Alphatec & Septerna appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.