Which has the lower trailing P/E, ASND or PEN?

ASND has the lower trailing P/E: ASND trades at 17.33 and PEN at 77.91. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ASND or PEN?

Over the past five years, ASND grew revenue faster — ASND at a 189.92% CAGR versus PEN at 17.52%.

Is ASND or PEN more profitable?

ASND runs the higher net margin — ASND at 71.08% versus PEN at 10.67%.

How have ASND and PEN total returns compared?

Over the past 10 years, ASND delivered 27.41% and PEN delivered 15.63% annualized total return. Past performance doesn't predict future results.

Ascendis Pharma A/S (ASND) vs Penumbra, Inc. (PEN)

A side-by-side comparison of Ascendis Pharma A/S and Penumbra, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ASND

Ascendis Pharma A/S

$14.16B

$228.03HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

PEN

Penumbra, Inc.

$12.49B

$317.11HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT

Total return — ASND vs PEN

growth of $100 · dividends reinvested · last 10y

ASND +1027.2% (+27.4%/yr)PEN +327.2% (+15.6%/yr)ASND compounded faster over this window

ASND PEN

ASND vs PEN: by the numbers

•ASND is the larger company ($14.16B vs $12.49B market cap).
•ASND trades at the lower trailing earnings multiple (17.33 vs 77.91 P/E), one valuation lens rather than an overall verdict.
•ASND converts more revenue to profit (71.08% vs 10.67% net margin).
•ASND grew revenue faster over the past five years (189.92% vs 17.52% CAGR).

Metrics side by side

Valuation

Metric	ASND	PEN
P/E ratio	17.33	77.91
Forward P/E	N/A	67.36
P/S ratio	11.59	8.30
P/B ratio	8.64	8.16
EV / EBITDA	93.79	61.12
FCF yield	2.73%	1.73%

Profitability

Metric	ASND	PEN
Gross margin	90.18%	67.84%
Operating margin	-18.92%	12.45%
Net margin	71.08%	10.67%
ROE	52.97%	10.49%
ROIC	5.85%	8.48%

Growth (annualized)

Metric	ASND	PEN
Revenue CAGR (5Y)	189.92%	17.52%
Total return CAGR (5Y)	7.40%	4.16%

Frequently asked

Which has the lower trailing P/E, ASND or PEN?: ASND has the lower trailing P/E: ASND trades at 17.33 and PEN at 77.91. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ASND or PEN?: Over the past five years, ASND grew revenue faster — ASND at a 189.92% CAGR versus PEN at 17.52%.
Is ASND or PEN more profitable?: ASND runs the higher net margin — ASND at 71.08% versus PEN at 10.67%.
How have ASND and PEN total returns compared?: Over the past 10 years, ASND delivered 27.41% and PEN delivered 15.63% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ASND analysis Full PEN analysis Interactive comparison tool

Dig into the metrics

Ascendis Pharma A/S P/E ratio Penumbra P/E ratio Ascendis Pharma A/S ROE Penumbra ROE Ascendis Pharma A/S operating margin Penumbra operating margin Ascendis Pharma A/S revenue growth Penumbra revenue growth Ascendis Pharma A/S free cash flow Penumbra free cash flow

Ascendis Pharma A/S & Penumbra appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.