Assembly Biosciences, Inc. (ASMB) vs Prothena Corporation plc (PRTA)
A side-by-side comparison of Assembly Biosciences, Inc. and Prothena Corporation plc across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
ASMB
Assembly Biosciences, Inc.
$22.18HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
PRTA
Prothena Corporation plc
$8.02HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — ASMB vs PRTA
growth of $100 · dividends reinvested · last 10yASMB -76.4% (-13.4%/yr)PRTA -86.6% (-18.2%/yr)ASMB compounded faster over this window
ASMB PRTA
ASMB vs PRTA: by the numbers
- •ASMB is the larger company ($440M vs $420M market cap).
- •Both run net losses; ASMB's is the smaller (-0.06% vs -80.67% net margin).
- •PRTA grew revenue faster over the past five years (62.57% vs -1.78% CAGR).
Metrics side by side
Valuation
| Metric | ASMB | PRTA |
|---|---|---|
| P/E ratio | 40.33 | N/A |
| Forward P/E | N/A | 72.91 |
| P/S ratio | 5.87 | 7.70 |
| P/B ratio | 1.44 | 1.46 |
Profitability
| Metric | ASMB | PRTA |
|---|---|---|
| Gross margin | 99.82% | 61.77% |
| Operating margin | -11.75% | -1905.82% |
| Net margin | -0.06% | -80.67% |
| ROE | -0.01% | -15.33% |
| ROIC | -2.86% | -21.36% |
Growth (annualized)
| Metric | ASMB | PRTA |
|---|---|---|
| Revenue CAGR (5Y) | -1.78% | 62.57% |
| Total return CAGR (5Y) | -10.66% | -35.08% |
Frequently asked
- Which has grown faster, ASMB or PRTA?
- Over the past five years, PRTA grew revenue faster — ASMB at a -1.78% CAGR versus PRTA at 62.57%.
- How have ASMB and PRTA total returns compared?
- Over the past 10 years, ASMB delivered -13.41% and PRTA delivered -18.37% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Assembly Biosciences P/E ratioAssembly Biosciences ROEProthena ROEAssembly Biosciences operating marginProthena operating marginAssembly Biosciences revenue growthProthena revenue growthAssembly Biosciences free cash flowProthena free cash flow
Assembly Biosciences & Prothena appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.