Is ARWR or KRYS more profitable?

KRYS runs the higher net margin — ARWR at -47.79% versus KRYS at 54.82%.

How have ARWR and KRYS total returns compared?

Over the past 5 years, ARWR delivered 0.75% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Arrowhead Pharmaceuticals, Inc. (ARWR) vs Krystal Biotech, Inc. (KRYS)

A side-by-side comparison of Arrowhead Pharmaceuticals, Inc. and Krystal Biotech, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ARWR

Arrowhead Pharmaceuticals, Inc.

$8.57B

$60.83HealthcareDelayed quote: Oct 6, 2026, 10:50 AM EDT

KRYS

Krystal Biotech, Inc.

$9.49B

$321.90HealthcareDelayed quote: Oct 6, 2026, 10:45 AM EDT

Total return — ARWR vs KRYS

growth of $100 · dividends reinvested · last 9y

ARWR +1783.7% (+38.6%/yr)KRYS +3047.1% (+46.7%/yr)KRYS compounded faster over this window

ARWR KRYS

ARWR vs KRYS: by the numbers

•KRYS is the larger company ($9.49B vs $8.57B market cap).
•KRYS is profitable (54.82% net margin) while ARWR runs a net loss (-47.79%).

Metrics side by side

Valuation

Metric	ARWR	KRYS
P/E ratio	N/A	40.34
Forward P/E	N/A	42.31
P/S ratio	12.80	21.54
P/B ratio	18.41	6.98
EV / EBITDA	N/A	44.38
FCF yield	N/A	2.72%

Profitability

Metric	ARWR	KRYS
Gross margin	100.00%	93.34%
Operating margin	11.86%	44.93%
Net margin	-47.79%	54.82%
ROE	-68.73%	17.77%
ROIC	-12.12%	14.41%

Growth (annualized)

Metric	ARWR	KRYS
Revenue CAGR (5Y)	44.14%	N/A
Total return CAGR (5Y)	0.75%	44.28%

Frequently asked

Is ARWR or KRYS more profitable?: KRYS runs the higher net margin — ARWR at -47.79% versus KRYS at 54.82%.
How have ARWR and KRYS total returns compared?: Over the past 5 years, ARWR delivered 0.75% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ARWR analysis Full KRYS analysis Interactive comparison tool

Dig into the metrics

Krystal Biotech P/E ratio Arrowhead Pharmaceuticals ROE Krystal Biotech ROE Arrowhead Pharmaceuticals operating margin Krystal Biotech operating margin Arrowhead Pharmaceuticals revenue growth Krystal Biotech revenue growth Arrowhead Pharmaceuticals free cash flow Krystal Biotech free cash flow

Arrowhead Pharmaceuticals & Krystal Biotech appear in these rankings

Fastest Revenue Growth Stocks Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.