How have ARDX and SANA total returns compared?

Over the past 5 years, ARDX delivered 20.95% and SANA delivered -32.33% annualized total return. Past performance doesn't predict future results.

Ardelyx, Inc. (ARDX) vs Sana Biotechnology, Inc. (SANA)

A side-by-side comparison of Ardelyx, Inc. and Sana Biotechnology, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ARDX

Ardelyx, Inc.

$818M

$3.31HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

SANA

Sana Biotechnology, Inc.

$765M

$2.75HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ARDX vs SANA

growth of $100 · dividends reinvested · last 6y

ARDX +89.4% (+11.2%/yr)SANA -91.8% (-34.1%/yr)ARDX compounded faster over this window

Log scale — wide-divergence pair

ARDX SANA

ARDX vs SANA: by the numbers

•ARDX is the larger company ($818M vs $765M market cap).
•Both run net losses; SANA's is the smaller (0.00% vs -12.35% net margin).

Metrics side by side

Valuation

Metric	ARDX	SANA
P/S ratio	1.81	N/A
P/B ratio	5.49	4.95

Profitability

Metric	ARDX	SANA
Gross margin	93.96%	0.00%
Operating margin	-7.86%	0.00%
Net margin	-12.35%	0.00%
ROE	-37.38%	-137.04%
ROIC	-7.99%	-67.58%

Growth (annualized)

Metric	ARDX	SANA
Revenue CAGR (5Y)	105.14%	N/A
Total return CAGR (5Y)	20.95%	-32.33%

Frequently asked

How have ARDX and SANA total returns compared?: Over the past 5 years, ARDX delivered 20.95% and SANA delivered -32.33% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ARDX analysis Full SANA analysis Interactive comparison tool

Dig into the metrics

Ardelyx ROE Sana Biotechnology ROE Ardelyx operating margin Sana Biotechnology operating margin Ardelyx revenue growth Sana Biotechnology revenue growth Ardelyx free cash flow Sana Biotechnology free cash flow

Ardelyx & Sana Biotechnology appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.