Aprea Therapeutics, Inc. (APRE) vs SeaStar Medical Holding Corporation (ICU)
A side-by-side comparison of Aprea Therapeutics, Inc. and SeaStar Medical Holding Corporation across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
APRE
Aprea Therapeutics, Inc.
$0.66HealthcareDelayed quote: Oct 6, 2026, 10:45 AM EDT
ICU
SeaStar Medical Holding Corporation
$3.18HealthcareDelayed quote: Oct 6, 2026, 10:40 AM EDT
Total return — APRE vs ICU
growth of $100 · dividends reinvested · last 4yAPRE -95.0% (-52.8%/yr)ICU -99.9% (-80.7%/yr)APRE compounded faster over this window
Log scale — wide-divergence pair
APRE ICU
APRE vs ICU: by the numbers
- •ICU is the larger company ($9M vs $8M market cap).
- •Both run net losses; APRE's is the smaller (0.00% vs -795.50% net margin).
Metrics side by side
Valuation
| Metric | APRE | ICU |
|---|---|---|
| P/S ratio | N/A | 5.26 |
| P/B ratio | 0.21 | 2.10 |
Profitability
| Metric | APRE | ICU |
|---|---|---|
| Gross margin | 0.00% | 92.64% |
| Operating margin | 0.00% | -986.63% |
| Net margin | 0.00% | -795.50% |
| ROE | -31.99% | -317.20% |
| ROIC | -33.73% | -325.63% |
Growth (annualized)
| Metric | APRE | ICU |
|---|---|---|
| Total return CAGR (5Y) | -63.30% | N/A |
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.