Annexon, Inc. (ANNX) vs Collegium Pharmaceutical, Inc. (COLL)
A side-by-side comparison of Annexon, Inc. and Collegium Pharmaceutical, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
ANNX
Annexon, Inc.
$4.20HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
COLL
Collegium Pharmaceutical, Inc.
$21.87HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
Total return — ANNX vs COLL
growth of $100 · dividends reinvested · last 6yANNX -76.4% (-21.4%/yr)COLL +25.1% (+3.8%/yr)COLL compounded faster over this window
Log scale — wide-divergence pair
ANNX COLL
ANNX vs COLL: by the numbers
- •COLL is the larger company ($709M vs $688M market cap).
- •COLL is profitable (5.93% net margin) while ANNX runs a net loss (0.00%).
Metrics side by side
Valuation
| Metric | ANNX | COLL |
|---|---|---|
| P/E ratio | N/A | 17.64 |
| PEG ratio | N/A | 0.99 |
| P/S ratio | N/A | 0.88 |
| P/B ratio | 3.70 | 2.27 |
| EV / EBITDA | N/A | 2.84 |
| FCF yield | N/A | 46.28% |
Profitability
| Metric | ANNX | COLL |
|---|---|---|
| Gross margin | 0.00% | 60.02% |
| Operating margin | 0.00% | 19.61% |
| Net margin | 0.00% | 5.93% |
| ROE | -108.93% | 15.36% |
| ROIC | -101.43% | 6.11% |
Growth (annualized)
| Metric | ANNX | COLL |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 19.91% |
| EPS CAGR (5Y) | N/A | 20.48% |
| FCF CAGR (5Y) | N/A | 26.38% |
| Total return CAGR (5Y) | -26.29% | 2.15% |
Frequently asked
- Is ANNX or COLL more profitable?
- COLL runs the higher net margin — ANNX at 0.00% versus COLL at 5.93%.
- How have ANNX and COLL total returns compared?
- Over the past 5 years, ANNX delivered -26.29% and COLL delivered 2.15% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Collegium Pharmaceutical P/E ratioAnnexon ROECollegium Pharmaceutical ROEAnnexon operating marginCollegium Pharmaceutical operating marginAnnexon revenue growthCollegium Pharmaceutical revenue growthAnnexon free cash flowCollegium Pharmaceutical free cash flow
Annexon & Collegium Pharmaceutical appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.