Is ANAB or TSHA more profitable?

ANAB runs the higher net margin — ANAB at 82.37% versus TSHA at -2728.04%.

How have ANAB and TSHA total returns compared?

Over the past 5 years, ANAB delivered 21.54% and TSHA delivered -25.17% annualized total return. Past performance doesn't predict future results.

AnaptysBio, Inc. (ANAB) vs Taysha Gene Therapies, Inc. (TSHA)

A side-by-side comparison of AnaptysBio, Inc. and Taysha Gene Therapies, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ANAB

AnaptysBio, Inc.

$1.42B

$47.89HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

TSHA

Taysha Gene Therapies, Inc.

$1.40B

$4.39HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ANAB vs TSHA

growth of $100 · dividends reinvested · last 6y

ANAB +398.5% (+30.7%/yr)TSHA -81.3% (-24.4%/yr)ANAB compounded faster over this window

Log scale — wide-divergence pair

ANAB TSHA

ANAB vs TSHA: by the numbers

•ANAB is the larger company ($1.42B vs $1.40B market cap).
•ANAB is profitable (82.37% net margin) while TSHA runs a net loss (-2728.04%).

Metrics side by side

Valuation

Metric	ANAB	TSHA
P/E ratio	8.92	N/A
P/S ratio	5.97	256.01
P/B ratio	133.96	3.63
EV / EBITDA	11.44	N/A
FCF yield	1.27%	N/A

Profitability

Metric	ANAB	TSHA
Gross margin	98.97%	100.00%
Operating margin	20.42%	-1130.65%
Net margin	82.37%	-2728.04%
ROE	1849.06%	-38.64%
ROIC	47.55%	-34.46%

Growth (annualized)

Metric	ANAB	TSHA
Revenue CAGR (5Y)	18.60%	N/A
FCF CAGR (5Y)	27.41%	N/A
Total return CAGR (5Y)	21.54%	-25.17%

Frequently asked

Is ANAB or TSHA more profitable?: ANAB runs the higher net margin — ANAB at 82.37% versus TSHA at -2728.04%.
How have ANAB and TSHA total returns compared?: Over the past 5 years, ANAB delivered 21.54% and TSHA delivered -25.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ANAB analysis Full TSHA analysis Interactive comparison tool

Dig into the metrics

AnaptysBio P/E ratio AnaptysBio ROE Taysha Gene Therapies ROE AnaptysBio operating margin Taysha Gene Therapies operating margin AnaptysBio revenue growth Taysha Gene Therapies revenue growth AnaptysBio free cash flow Taysha Gene Therapies free cash flow

AnaptysBio & Taysha Gene Therapies appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.