Is ANAB or GHRS more profitable?

ANAB runs the higher net margin — ANAB at 82.37% versus GHRS at 0.00%.

How have ANAB and GHRS total returns compared?

Over the past 5 years, ANAB delivered 21.54% and GHRS delivered 0.52% annualized total return. Past performance doesn't predict future results.

AnaptysBio, Inc. (ANAB) vs GH Research PLC (GHRS)

A side-by-side comparison of AnaptysBio, Inc. and GH Research PLC across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ANAB

AnaptysBio, Inc.

$1.42B

$47.84HealthcareDelayed quote: Oct 6, 2026, 1:05 PM EDT

GHRS

GH Research PLC

$1.48B

$21.53HealthcareDelayed quote: Oct 6, 2026, 1:05 PM EDT

Total return — ANAB vs GHRS

growth of $100 · dividends reinvested · last 5y

ANAB +194.8% (+24.1%/yr)GHRS +15.2% (+2.9%/yr)ANAB compounded faster over this window

ANAB GHRS

ANAB vs GHRS: by the numbers

•GHRS is the larger company ($1.48B vs $1.42B market cap).
•ANAB is profitable (82.37% net margin) while GHRS runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	ANAB	GHRS
P/E ratio	8.91	N/A
P/S ratio	5.96	N/A
P/B ratio	133.82	4.11
EV / EBITDA	11.43	N/A
FCF yield	1.27%	N/A

Profitability

Metric	ANAB	GHRS
Gross margin	98.97%	0.00%
Operating margin	20.42%	0.00%
Net margin	82.37%	0.00%
ROE	1849.06%	-17.32%
ROIC	47.55%	-19.87%

Growth (annualized)

Metric	ANAB	GHRS
Revenue CAGR (5Y)	18.60%	N/A
FCF CAGR (5Y)	27.41%	N/A
Total return CAGR (5Y)	21.54%	0.52%

Frequently asked

Is ANAB or GHRS more profitable?: ANAB runs the higher net margin — ANAB at 82.37% versus GHRS at 0.00%.
How have ANAB and GHRS total returns compared?: Over the past 5 years, ANAB delivered 21.54% and GHRS delivered 0.52% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ANAB analysis Full GHRS analysis Interactive comparison tool

Dig into the metrics

AnaptysBio P/E ratio AnaptysBio ROE GH Research ROE AnaptysBio operating margin GH Research operating margin AnaptysBio revenue growth GH Research revenue growth AnaptysBio free cash flow GH Research free cash flow

AnaptysBio & GH Research appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest ROIC Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.